Recombinant Human Fibroblast growth factor 10 protein(FGF10) (Active)

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Code CSB-AP002441HU
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Product Details

Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0x106 IU/mg.
Target Names FGF10
Uniprot No. O15520
Research Area Cancer
Alternative Names BB213776 ; fd11d03; FGF 10; FGF-10; FGF10; FGF10_HUMAN; Fibroblast growth factor 10; Keratinocyte growth factor 2; KGF 2; Produced by fibroblasts of urinary bladder lamina propria; wu:fd11d03; zgc:109774
Species Homo sapiens (Human)
Source E.coli
Expression Region 40-208aa
Complete Sequence LGQDMVSPEA TNSSSSSFSS PSSAGRHVRS YNHLQGDVRW RKLFSFTKYF LKIEKNGKVS GTKKENCPYS ILEITSVEIG VVAVKAINSN YYLAMNKKGK LYGSKEFNND CKLKERIEEN GYNTYASFNW QHNGRQMYVA LNGKGAPRRG QKTRRKNTSA HFLPMVVHS
Mol. Weight 19.1 kDa
Protein Length Partial
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered 2 × PBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
Gene References into Functions
  1. We report the ophthalmological and genetic study of a 19-year-old woman and her relatives suffering from this syndrome. A new probably pathogenic variant is described in the FGF10 gene. PMID: 29053399
  2. We have revealed significant association of FGFR2 and MAP3K1 polymorphisms with breast cancer. PMID: 29372690
  3. data suggest that the strongest signal of association at 5p12 is mediated through coordinated activation of FGF10 and MRPS30, two candidate genes for breast cancer pathogenesis PMID: 27640304
  4. Fgf10 signaling has an essential role in the formation of lipofibroblasts during late lung development PMID: 26511927
  5. Expression of Fibroblast Growth Factor 10 is correlated with poor prognosis in gastric adenocarcinoma. PMID: 26268776
  6. FGF10 has a role in protecting neuron against oxygen-glucose deprivation injury through inducing heme oxygenase-1 PMID: 25446127
  7. Data identify autocrine activation of FGF signaling as an essential mechanism in promoting Pten-deficient skin tumors. PMID: 24582960
  8. The therapeutic potential of the FGF10 treatment. PMID: 24865969
  9. FGF10 plays an important role for tumor growth by both paracrine and autocrine manner. PMID: 24320134
  10. The findings show that immunohistochemistry with FGF10, FGFR2b, or SHH could be useful in differentiating CCAM from type I PPB, when a child presents with a focal cystic lung lesion. PMID: 24004862
  11. Paracrine FGF10 signaling stimulates the differentiation of human stem cell into urothelial cells. PMID: 23949743
  12. High FGF10 expression is associated with ameloblastoma. PMID: 24002438
  13. Three FGF10 single nucleotide polymorphisms in complete linkage disequilibrium--rs339501, rs12517396, and rs10462070--were associated with extreme myopia in the Japanese population. PMID: 24265547
  14. FGF-10 expression during the development of the human hindgut and anorectum suggests that it may play a role in hindgut and anorectal morphogenesis. PMID: 23774963
  15. The sclera of myopic eyes had higher FGF10 levels. The risk G allele of SNP rs339501 was associated with extreme myopia in human and caused a higher gene expression in the luciferase assay. PMID: 23599340
  16. the posttranslational and transcriptional mechanisms underlying stimulation of P-glycoprotein function and expression by keratinocyte growth factor-2 (KGF2) that may contribute to the beneficial effects of KGF2 in intestinal inflammatory disorders PMID: 23328208
  17. tooth agenesis had increased risk of a family history of cancer. tooth agenesis was associated with positive self-reported family history of cancer and variants in FGF10. PMID: 23169889
  18. Identification of FGF-10 at both protein and mRNA levels in ovaries from fetuses, girls, and women suggests that FGF-10 contributes to preantral follicle development; FGF-10 is expressed in both granulosa cells and oocytes. PMID: 22877940
  19. Our data suggest that common variants in FGF10 increase the risk for a wide range of non-syndromic limb deficiencies. PMID: 22965740
  20. [review] FGF10 mediates biological responses by activating FGF receptor 2b (FGFR2b) in a paracrine manner. PMID: 21696361
  21. The relationship between human ISL1 and FGF10 within the embryonic time window during which the linear heart tube remodels into four chambers, was examined. PMID: 22303449
  22. Investigation of the pulmonary functions of COPD patients heterozygous for loss of function mutations in the FGF10 gene was performed. The patients show a significant decrease in lung function parameters when compared to control values. PMID: 21742743
  23. Gremlin-mediated BMP inhibition results in activation of epithelial cells and transient fibrosis, but also induction of epithelium-protective FGF10 PMID: 20705941
  24. FGF2 and FGF10 regulate migratory activity of ovine trophoblast cells through MAPK-dependent pathways. PMID: 21310815
  25. FGF10 can promote the adipogenesis effect in situ. PMID: 19915940
  26. There was no association among gene FGFR1 rs13317, p. E467K, p. M369I, p. S393S and gene FGF10 rs1448037 and nonsyndromic cleft lip with or without palate in Chinese population. PMID: 19727229
  27. These results suggested that Thr-114 is a crucial functional residue for FGF10, and mutating Thr-114 to Ala or Arg would lead to great decrease in receptor-binding affinity and biological activity of FGF10. PMID: 20036575
  28. FGF10 upregulates Na(+)-K(+)-exchanging ATPase via the MAPK pathway. PMID: 12804770
  29. FGF-10 attenuates H2O2-induced alveolar epithelium DNA damage by mechanisms that involve activation of Grb2-SOS/Ras/RAF-1/ERK1/2 pathway and DNA repair. PMID: 14975937
  30. Fgf10 mRNA is overexpressed in a subset of human breast carcinomas. PMID: 15208658
  31. Data validate the symmetric two-end model of fibroblast growth factor (FGF) receptor (FGFR) dimerization and FGF binding and argue against the asymmetric model of FGFR dimerization. PMID: 15632068
  32. We suggest that haploinsufficiency for FGF10 during a crucial stage of development results in ALSG. PMID: 15654336
  33. Human embryonic pancreatic mesenchyme expresses FGF10, which might be used used to expand human embryonic pancreatic epithelial cells. PMID: 15690149
  34. Human recombinant FGF10 maintains murine Notch activation and induces the expansion of murine pancreatic precursors while blocking their differentiation. PMID: 16323074
  35. Localization of the FGF-10 receptor to the urothelial layer is clinically significant because intravesical administration of FGF-10 may provide a means to control the turnover of transitional epithelium in bladder disorders such as interstitial cystitis. PMID: 16597614
  36. Activation of Toll-like receptor 2 (TLR2) or Toll-like receptor 4 (TLR4) inhibited FGF-10 expression, leading to abnormal saccular airway morphogenesis. PMID: 17071719
  37. R80S and G138E mutations are associated with aplasia of the lacrimal and salivary glands. PMID: 17213838
  38. a nuclear localization signal-like motif of FGF-10 is a partial determinant of its intracellular distribution and is necessary for its mitogenic activity PMID: 17471512
  39. Trophoblast outgrowth and invasion (part of placental villi sprouting) at the fetal maternal interface is in part under delicate control of FGF 10 and Sprouty 2. PMID: 17496316
  40. Results suggest that Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway. PMID: 17682060
  41. Expression in diverse niches of adult brain of Fgf10-lacZ reporter mice implicates Fgf10 in control of neurogenesis and/or conservation of neurogenic potential. PMID: 18329286
  42. It cannot be ruled out that other genes involved in the signalling pathway of FGF10 may contribute to the formation of these congenital malformations. PMID: 18587586
  43. Stromal FGF10 induces migration and invasion in pancreatic cancer cells through interaction with FGFR2, resulting in a poor prognosis. PMID: 18594526
  44. family-based approach revealed an intronic variation of the FGF10 gene causing aplasia of lacrimal and salivary glands-syndrome PMID: 19102732
  45. Disruption of localized pattern of mesenchymal fibroblast growth factor 10 expression results in impairment of lung branching morphogenesis, which progresses to emphysematous airspaces in adults. PMID: 19115389
  46. Fgf10 is a strong causative candidate for defects observed in Apert syndrome since its genetic knockdown in a mouse model of Apert syndrome results in the rescue of the skeletal and visceral defects associated with this congenital disease. PMID: 18773495
  47. An analysis of the distribution and fate of Fgf10-expressing cells in the adult mouse brain suggests that Fgf10 may have critical regulatory roles in stem cell function and generation of new neurons in diverse areas of the adult brain. PMID: 18773495
  48. TGFbeta1 caused a rapid and transient decrease in Fgf10 mRNA levels in primary prostatic cells. Deletion analysis of the Fgf10 promoter identified a region that mediated a proportion of promoter activity as well as promoter down-regulation by TGFbeta1. PMID: 14726452

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Involvement in disease Aplasia of lacrimal and salivary glands (ALSG); Lacrimo-auriculo-dento-digital syndrome (LADDS)
Subcellular Location Secreted
Protein Families Heparin-binding growth factors family
Database Links

HGNC: 3666

OMIM: 149730

KEGG: hsa:2255

STRING: 9606.ENSP00000264664

UniGene: Hs.248049

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