Recombinant Human Interleukin-37(IL37),partial (Active)

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Code CSB-AP004431HU
Size US$3267Purchase it in Cusabio online store
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity The ED50 as determined by its ability to bind Human IL-18R beta in functional ELISA is less than 10 ug/ml.
Target Names IL37
Uniprot No. Q9NZH6
Research Area Immunology
Alternative Names FIL1; FIL1 zeta; FIL1(ZETA); FIL1Z; IL 1 zeta; IL 1F7; IL 1F7b (IL 1H4; IL 1H; IL 1RP1) ; IL 1H4; IL 1RP1; IL 1X; IL 1X protein; IL-1 zeta; IL-1F7; IL-1H; IL-1H4; IL-1RP1; IL-1X; IL-37; IL1F7 (canonical product IL 1F7b) ; IL1F7; IL1F7_HUMAN; IL1H4; IL1RP1; Interleukin 1 family member 7; interleukin 1 family; member 7 (zeta); Interleukin 1 homolog 4; Interleukin 1 related protein; Interleukin 1 superfamily z; Interleukin 1 zeta; Interleukin 37; Interleukin-1 family member 7; Interleukin-1 homolog 4; Interleukin-1 zeta; Interleukin-1-related protein; Interleukin-23
Species Homo sapiens (Human)
Source E.coli
Expression Region 53-218aa
Mol. Weight 18.7 kDa
Protein Length Partial
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, 2 mM DTT, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Gene References into Functions
  1. a genome wide association study for "high" gingival crevicular fluid IL-1beta expression among 4910 European-American adults and identify association signals in the IL37 locus, is reported. PMID: 30206230
  2. IL-37 can be secreted extracellularly, and binds to IL-18Ra chain and recruits Toll/IL-1R (TIR)-8 for transducing anti-inflammatory signaling. IL-37 is upregulated in an inducible manner and negatively regulates signaling mediated by TLR agonists and pro-inflammatory cytokines. PMID: 28548248
  3. Our results showed that IL-37 plays an inhibitory role in non-small cell lung cancer progression, possibly by suppressing STAT3 activation and decreasing epithelial-to-mesenchymal transition by inhibiting IL-6 expression. IL-37 could serve as a potential novel tumor suppressor in non-small cell lung cancer PMID: 29575809
  4. TIM-3 and IL-37 may be used as potential biomarkers of active rheumatoid arthritis. PMID: 30106887
  5. This study suggests that human IL-37 overexpressed in mice reduces lean body mass by reducing food intake. PMID: 30072596
  6. These data suggest that IL37 is a new susceptibility gene for Coronary artery disease (CAD), which provides a potential target for the prevention and treatment of CAD PMID: 28181534
  7. In allergic rhinits patients, the IL-1R8 ligand IL-37 could potentially modulate aberrant immune responses by attenuating IL-17 and IL-4 production by CD4+ T cells. PMID: 29730558
  8. Review of role of interleukin 37 in physiology and disease. PMID: 29805973
  9. this study shows that Interleukin-37 alleviates airway inflammation and remodeling in asthma via inhibiting the activation of NF-kappaB and STAT3 signalings PMID: 29268192
  10. IL1F7 gene polymorphism does not significantly influence rheumatoid arthritis susceptibility in the Northern Chinese Han population. PMID: 29336365
  11. IL37 may be an important cytokine in the pathogenesis of allergic rhinitis. PMID: 29115624
  12. results suggest that there was a low level of interleukin 37 in the eutopic and ectopic endometria of patients with adenomyosis PMID: 28762845
  13. Study concludes that recombinant human interleukin-37 enhances the suppressive activity of CD4(+)CD25(+) regulatory T cells and might be a potential immunomodulator for the treatment of septic complications. PMID: 27941849
  14. IL-37 level is elevated in systemic lupus erythematous patients in comparison to healthy controls and is correlated to high disease activity, mucocutaneous and renal involvement. PMID: 28627005
  15. An association of IL-37 single nucleotide polymorphism rs3811047 with Behcet's disease, but not Vogt-Koyanagi-Harada disease in Han Chinese. PMID: 27775096
  16. The data suggest that IL-10, but not IL-37, may have potential as a biomarker predictive for disease activity in Systemic lupus erythematosus. PMID: 27708376
  17. this study shows that IL-37 causes excessive inflammation and tissue damage in murine pneumococcal pneumonia PMID: 28601872
  18. common genetic variants of IL37 lead to different immune-inhibitory potencies. PMID: 27665946
  19. IL-37 increased from normal control (NC) to oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC). IL-37 expression was lower in OSCC with lymph node metastasis than those without metastasis. IL-37 overexpression in RAW264.7 cells remarkably reduced the pseudopodia, vacuolization and the expression of IL-6, TNF-alpha, and IL-1beta. IL-37 and IL-18Ralpha but not IL-18BP have similar expression and location in ... PMID: 27225603
  20. We conclude that under low-grade inflammatory conditions, hematopoietic IL-37 expression reduces the inflammatory state, but does not influence atherosclerosis development in hyperlipidemic LDLr-deficient mice. PMID: 28792474
  21. The IL- 37 (rs3811047) polymorphism contributes to the development of ADs in a Chinese population. PMID: 29642198
  22. IL-37 is produced primarily by CD4+ T cells and vascular smooth muscle cells and that it plays a protective role in atherosclerotic injury by directing a switch in CD4+ T lymphocyte phenotypes in addition to directly regulating the expression of caspase-3 to reduce H2O2- and pro-inflammatoryinduced SMC apoptosis. PMID: 29439249
  23. Blocking IL-1 with IL-37 alleviates the symptoms in patients with inflammatory diseases including arteriosclerosis. The impact of IL-37 on inflammatory cytokines mediating atherosclerosis is beneficial and protective. PMID: 28420489
  24. these data highlight the importance of IL-37 in the cell proliferation and progression of hepatocellular carcinoma PMID: 27835881
  25. Serum Il-37 level is significantly increased in acute coronary syndrome. IL-37 may exert a cardioprotective effect by suppressing ROCK activity. PMID: 28039466
  26. this study found that IL-37 levels in peritoneal fluid and in serum were significantly higher in patients with endometriosis compared to women without endometriosis PMID: 28322860
  27. IL-37 profile in patients with acute coronary syndrome and the increased IL-37 concentration was associated with a worse clinical in-hospital outcome in STEMI patients undergoing PPCI PMID: 28237549
  28. this study shows that human IL-37 inhibited LPS-induced mouse osteoclast formation and bone resorption via inhibition of LPS-induced osteoclast related cytokines PMID: 27154248
  29. serum IL-37 and its mRNA expression is increased in Ankylosing spondylitis (AS) patients with special consideration in patient with Osteoporosis and correlates with disease activity and BMD which indicate that IL-37 may provide a novel research target for pathogenesis and therapy of AS. PMID: 28502149
  30. this study shows that macrophage-specific expression of IL-37 in hyperlipidemic mice attenuates atherosclerosis PMID: 29030487
  31. IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in S. stercoralis infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection. PMID: 28874444
  32. constitutive IL-37 secretion by myeloid dendritic cells may serve to maintain an anti-inflammatory milieu at steady state, whereas IL-37 is stored in monocytes to be available for rapid release upon inflammatory encounters. PMID: 27881605
  33. IL-37 regulates autophagy in SMMC-7721 and Huh-7 cells via inhibition of the PI3K/AKT/mTOR signaling pathway. PMID: 28433890
  34. IL-37 inhibited the proliferation of hepatocellular carcinoma SMMC-7721 cells. PMID: 28395710
  35. these findings reveal that intracellular IL-37b is a critical factor in the negative regulation of multiple signaling pathways that modulate the expression of metastasis-related genes PMID: 28092676
  36. IL-37 may be employed as a new molecular target for the therapy and diagnosis of Tuberculosis. PMID: 28076390
  37. IL37 itself reduced IL1beta, IL6 and IL8 production in osteoarthritis chondrocytes, indicating that IL37 is able to induce a counter-regulatory anti-inflammatory feedback loop in chondrocytes. In addition, IL37 dampens catabolic enzyme expression. PMID: 27940589
  38. IL-37 is elevated in AF patients and its expression is closely associated with AF subgroups. Thus, IL-37 may provide a novel research target for the pathogenesis and therapy of AF. PMID: 28244597
  39. These results indicate that a decreased IL-37 expression by colon epithelial cells may be an important factor for increasing the recruitment of immune cells and subsequently developing microscopic colitis. PMID: 28044228
  40. reviewed the updated evidence indicating the roles of IL-35 and IL-37 in asthma PMID: 27878686
  41. serum level of IL-37 plays a part in the pathophysiology of multiple myeloma progression. PMID: 27807338
  42. this study shows that IL-37 could decrease both NF-kappaB and ICAM-1 expression upon TLR2 activation in human coronary artery endothelial cells, and that this effect may be due to its inhibition on NF-kappaB PMID: 27233003
  43. Results show that elevated plasma IL-37 level and its associations with anti-Sm, anti-RNP and C3 in systemic lupus erythematosus patients suggest that IL-37 may be implicated in this disease. PMID: 27125292
  44. the present data suggest that rs2723176 SNP of IL-37 is involved in the development of TB infection. PMID: 27761939
  45. this study reviews the role of IL-37 as a key suppressor of asthma mediated by mast cells PMID: 27982737
  46. In the discovery phase, two nonsynonymous SNPs (rs3811046 and rs3811047), located in the IL1F7 gene and in an intergenic region, respectively were found to be weakly associated with non-high tension glaucoma cases. PMID: 27533638
  47. CCL22 and IL-37 with a co-localization in the A549 cells inhibited the proliferation PMID: 27499437
  48. increased IL-37 concentrations are associated with the onset of arterial calcification PMID: 27451144
  49. These findings suggest that increased expression of IL-37 was present in eutopic and ectopic endometrium of women with ovarian endometriosis, which might be involved in the inflammatory process of endometriomas. PMID: 26342048
  50. These fi ndings suggest that elevation of HLA-G and IL-37 in hepatitis C virus may play an important role in response to combined therapy with interferon-apha and ribovirin. PMID: 27112970
  51. Findings show IL-37 mRNA and protein expressions significantly decreased in non-small cell lung cancer and demonstrate its protective role possibly through inhibiting tumor angiogenesis. PMID: 26791086
  52. IL-37 is an important cytokine in the control of asthma by suppressing the production of inflammatory cytokines. PMID: 26454413
  53. Letter: Expression of IL-37 is decreased in psoriatic skin. PMID: 26319074
  54. IL-37 is an important anti-inflammatory cytokine in the control of RA pathogenesis by suppressing inflammatory cytokine production PMID: 26159110
  55. The serum level of IL-37 was found to be significantly increased in multiple sclerosis and neuromyelitis optica patients compared to healthy controls. PMID: 26008726
  56. These results demonstrated that IL-37 might manifest as a critical protein involving in immunosuppression of human CD4(+)CD25(+)Tregs. PMID: 26411375
  57. Our study strongly supports that the IL37 gene variants are associated with the susceptibility to AITD. PMID: 26373794
  58. The expression of IL-37 was decreased in renal cell carcinoma patients and was negatively correlated with tumor progression. PMID: 26464282
  59. these data suggest a special role for IL-37 in asthma pathogenesis PMID: 26561030
  60. Interleukin-37 expression is decreased in Behcet's disease and is associated with inflammation PMID: 26253248
  61. tubular epithelial cells express the IL-18 contra-regulatory protein IL-37 as an endogenous control mechanism to reduce inflammation PMID: 25207880
  62. research demonstrated, for the first time, that anti-inflammatory active components (triptolide and triptonide) upregulated the expression of IL-37 most likely via activation of the ERK1/2 and p38 MAPK pathways. PMID: 25308753
  63. our data shows that the level of IL-37 mRNA is affected by chronic HIV-1-infection. PMID: 25879630
  64. The results suggest serum IL-37 levels were increased in rheumatoid arthritis (RA) patients and were positively associated with disease activity, IL-17/IL-23 and bone loss in RA, suggesting that IL-37 may play a critical role in the pathogenesis of RA. PMID: 26547368
  65. Suggest that IL-37 is a novel and potent proangiogenic cytokine. PMID: 26515414
  66. IL-37 does not play an important role in the systematic inflammatory response but may be involved in leukocytic inflammation in ASTEMI after percutaneous coronary intervention PMID: 25960620
  67. Thus, this method provides an efficient way to obtain an active IL-37 with high yield and high purity. PMID: 25559248
  68. Higher levels of IL-37 were found in ankylosing spondylitis patients, which were correlated with disease activity. PMID: 25627863
  69. IL-37 may be a novel research target to understand the pathogenesis of tuberculosis infection. PMID: 26073153
  70. IL-37 requires IL-18Ralpha and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice PMID: 25557042
  71. Low Interleukin-37 expression is associated with hepatocellular carcinoma. PMID: 24898887
  72. IL-37 as an important anti-inflammatory modulator during obesity-induced inflammation and insulin resistance. PMID: 25182023
  73. hBD-3 stimulates IL-37 expression through CCR6 in keratinocytes PMID: 25541254
  74. Patients with active pulmonary tuberculosis present with significantly increased level of plasma IL-37. PMID: 25854573
  75. IL-37 plays a potent immunosuppressive role in the pathogenesis of human rheumatoid arthritis and mouse collagen-induced arthritis models via the downregulation of IL-17 and IL-17-triggering cytokine production and the curbing of Th17 cell proliferation. PMID: 25917106
  76. the expression of IL-37 is correlated with the disease activity of GD, and contribute to suppress inflammation cytokines TNF-alpha, IL-6, and IL-17 during GD pathogenesis. PMID: 25226272
  77. IL-37 requires the receptors IL-18Ralpha and IL-1R8 to carry out its multifaceted anti-inflammatory program upon innate signal transduction. PMID: 25729923
  78. IL-35 and IL-37 protein expressions were higher in IBD patients compared with controls. PMID: 25214710
  79. IL-37 acts as an extracellular cytokine by binding to the IL-18 receptor but using the IL-1R8 for its anti-inflammatory properties. PMID: 25654981
  80. DCs expressing IL-37 are tolerogenic, thereby impairing activation of effector T-cell responses and inducing Treg cells PMID: 25294929
  81. show here that IL1A, IL1B and IL1F7 regulatory regions come in close proximity in LPS stimulated cells but not in resting human monocytes PMID: 24787052
  82. We conclude that a decreased IL-37 expression in active BD patients may trigger the production of pro-inflammatory cytokines and ROS in association with activation of Th1 and Th17 cells by DCs. PMID: 24730521
  83. IL-37 expression in RA and during DMARD treatment appears to be controlled by the level of pro-inflammatory cytokines. This results in a strong correlation between plasma levels of IL-37 and disease activity in RA patients. PMID: 24788826
  84. plasma IL-37 levels are associated with the onset of acute coronary syndrome PMID: 24733959
  85. Data indicate that anti-IL-37 antibody with high titer and specificity was successfully prepared. PMID: 24796748
  86. Downregulation of IL-37 expression appeared to result in overexpression of pro-inflammatory cytokines in degenerative disc disease. PMID: 24551286
  87. IL-37 associated with SLE disease activity, especially related with systemic Lupus erythematosus renal disease activity. PMID: 24629023
  88. functional polymorphism, IL1f7 rs3811047 G>A, might contribute to gastric cardiac adenocarcinoma (GCA) susceptibility. PMID: 24357513
  89. cerebrospinal fluid and plasma interleukin-37 are elevated and may play a role in Guillain-Barre syndrome PMID: 24174711
  90. that IL-37 may play a significant role in the immune response of CHB patients with HBeAg seroconversion. The serum levels of IL-37 are associated with liver damage in CHB patients. PMID: 23697556
  91. these studies strongly indicate that IL-37 plays a potent immunosuppressive role in the pathogenesis of both experimental psoriasis models in vitro and in vivo by downregulating proinflammatory cytokines. PMID: 24453242
  92. Although caspase-1 is required for nuclear translocation of intracellular IL-37 and for secretion of mature IL-37, the release of the IL-37 precursor is independent of caspase-1 activation. PMID: 24481253
  93. the A allele of IL-1F7 gene (rs3811047) may have a protective effect on rheumatoid arthritis. PMID: 23171316
  94. IL37 may play a role in the pathogenesis of atopic dermatitis by modulating innate immune reactions. PMID: 23182761
  95. IL-37b may be involved in the pathophysiology of inflammatory bowel disease as an anti-inflammatory cytokine and an inhibitor of both innate and acquired immune responses. PMID: 23600829
  96. Data indicate that IL-1alpha binds stronger to nuclear structures than IL-33 and IL-37. PMID: 23159404
  97. IL-37 is protective against hepatic ischemia-reperfusion injury. PMID: 22646996
  98. Data show that weight loss led to a significant reduction in liver IL-1beta, IL-18 and IL-1Ra expression, whereas hepatic IL-37 expression remained stable, adipose/liver NLRP3 inflammasome and IL-1alpha expression were not affected by weight loss. PMID: 21394384
  99. IL-37 is a key modulator of intestinal inflammation, and its expression protects mice from experimental colitis. PMID: 21873195
  100. IL-37 thus emerges as a natural suppressor of innate inflammatory and immune responses PMID: 20935647

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Subcellular Location Cytoplasm, cytosol, Nucleus, Secreted
Protein Families IL-1 family
Tissue Specificity In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis,
Database Links

HGNC: 15563

OMIM: 605510

KEGG: hsa:27178

STRING: 9606.ENSP00000263326

UniGene: Hs.166371

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