ATG5 Monoclonal Antibody

Datasheet
Code CSB-MA172954
Product Type Monoclonal Antibody
Size US$167
Uniprot No. Q9H1Y0
Research Use Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Image
  • Immunohistochemical analysis of paraffin-embedded Human Ovarian Carcinoma Tissue using ATG5 Mouse mAb diluted at 1:200.

  • Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using ATG5 Mouse mAb diluted at 1:200.

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Protein
Raised in Mouse
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,IHC;Recommended dilution:IHC:1:50-1:200
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Alias Autophagy protein 5 (APG5-like) (Apoptosis-specific protein)
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
Involvement in disease Spinocerebellar ataxia, autosomal recessive, 25 (SCAR25)
Subcellular Location Cytoplasm, Preautophagosomal structure membrane, Peripheral membrane protein
Protein Families ATG5 family
Tissue Specificity Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
Database Links

HGNC: 589

OMIM: 604261

KEGG: hsa:9474

STRING: 9606.ENSP00000343313

UniGene: Hs.486063

Pathway Autophagy
NOD-like receptor signaling pathway

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