ATG5 Monoclonal Antibody

Datasheet
Code CSB-MA172954
Size US$167
Image
  • Immunohistochemical analysis of paraffin-embedded Human Ovarian Carcinoma Tissue using ATG5 Mouse mAb diluted at 1:200.

  • Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using ATG5 Mouse mAb diluted at 1:200.

Product Details

Uniprot No. Q9H1Y0
Alternative Names Autophagy protein 5 (APG5-like) (Apoptosis-specific protein)
Raised in Mouse
Species Reactivity Human,Mouse,Rat
Immunogen Recombinant Protein
Conjugate Non-conjugated
Purification Method The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Form Liquid
Tested Applications ELISA,IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Still Have Questions? Leave a Message or Start an on-line Chat

Target Data

Function Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
Involvement in disease Spinocerebellar ataxia, autosomal recessive, 25 (SCAR25)
Subcellular Location Cytoplasm, Preautophagosomal structure membrane, Peripheral membrane protein
Protein Families ATG5 family
Tissue Specificity Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
Database Links

HGNC: 589

OMIM: 604261

KEGG: hsa:9474

STRING: 9606.ENSP00000343313

UniGene: Hs.486063

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.