CBX5 Monoclonal Antibody

Datasheet
Code CSB-MA795112
Product Type Monoclonal Antibody
Size US$167
Uniprot No. P45973
Research Use Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Image
  • Immunohistochemical analysis of paraffin-embedded Human Placenta Tissue using HP-1α Mouse mAb diluted at 1:500

  • Immunohistochemical analysis of paraffin-embedded Human Placenta Tissue using HP-1α Mouse mAb diluted at 1:500

Immunogen Recombinant Protein
Raised in Mouse
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC;Recommended dilution:WB:1:500-1:5000,IHC:1:50-1:500
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Alias Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Subcellular Location Nucleus, Chromosome, Chromosome, centromere
Database Links

HGNC: 1555

OMIM: 604478

KEGG: hsa:23468

STRING: 9606.ENSP00000209875

UniGene: Hs.349283

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