CD8A Monoclonal Antibody,PE Conjugated

Datasheet
Code CSB-MA574619
Product Type Monoclonal Antibody
Size US$258
Protocols ELISA Protocol
Immunofluorescence (IF) Protocol
Flow Cytometry (FC) Protocol
Immunogen
Raised in Mouse
Species Reactivity Human
Specificity
Tested Applications ELISA,IF,FC;Recommended dilution:IF:1:100-1:200
Relevance

 COV8 reacts with the 32 kDa a chain of CD8. This molecule is expressed on the T suppressor/cytotoxic cell population (which comprises about 1/3 of the peripheral blood T lymphocytes total population) and with most of thymocytes, as well as a subset of NK cells. CD8 expresses as either a heterodimer with the CD8b chain (CD8ab) or as a homodimer (CD8aa or CD8bb). CD8 acts as a co-receptor with MHC Class I restricted TCRs in antigen recognition. CD8 function is important for positive selection of MHC Class I restricted CD8+ T cells during T cell development.

* Ratio of CD4 and CD8 is important for monitor of HIV infection.
 
1. Engleman EG et al. (1981) J Exp Med 153: 193-198.
2. Haynes, B et al. (1986) Leukocyte Typing II: Human T lymphocytes. New York: Sprimger-Verlag; 3-30.
3. Parnes, JR. et al. (1989). Adv. Immunol. 44,256-311.
4. Bikah G. et al. (1996). Science  274:1906.
Form Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA
Isotype IgG1
Clonality Monoclonal
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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