COL2A1 Monoclonal Antibody

Datasheet
Code CSB-MA217046
Product Type Monoclonal Antibody
Size US$167
Uniprot No. P02458
Research Use Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Image
  • Immunohistochemical analysis of paraffin-embedded Human Lung Carcinoma Tissue using Collagen II Mouse mAb diluted at 1:200

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthetic Peptide
Raised in Mouse
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,IHC;Recommended dilution:IHC:1:50-1:200
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Alias Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Involvement in disease Spondyloepiphyseal dysplasia congenital type (SEDC); Spondyloepiphyseal dysplasia, Stanescu type (SEDSTN); Spondyloepimetaphyseal dysplasia, Strudwick type (SEMDSTWK); Achondrogenesis 2 (ACG2); Legg-Calve-Perthes disease (LCPD); Kniest dysplasia (KD); Avascular necrosis of femoral head, primary, 1 (ANFH1); Osteoarthritis with mild chondrodysplasia (OSCDP); Platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T); Multiple epiphyseal dysplasia with myopia and conductive deafness (EDMMD); Spondyloperipheral dysplasia (SPD); Stickler syndrome 1 (STL1); Stickler syndrome 1 non-syndromic ocular (STL1O); Rhegmatogenous retinal detachment autosomal dominant (DRRD); Czech dysplasia (CZECHD)
Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families Fibrillar collagen family
Tissue Specificity Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte.
Database Links

HGNC: 2200

OMIM: 108300

KEGG: hsa:1280

STRING: 9606.ENSP00000369889

UniGene: Hs.408182

Pathway PI3K-Akt signaling pathway
Focal adhesion

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