CTDSP2 Monoclonal Antibody

Datasheet

Code	CSB-MA061514
Size	US$210
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Image	Flow cytometric analysis of CTD small phosphatase 2 expression in HepG2 cells using CTD small phosphatase 2 antibody. Green, isotype control; red, CTD small phosphatase 2. Western blotting analysis using CTD small phosphatase 2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CTD small phosphatase 2 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
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Product Details
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Target Background

Product Details

Full Product Name

Mouse anti-Homo sapiens (Human) CTDSP2 Monoclonal antibody

Uniprot No.

O14595

Target Names

CTDSP2

Alternative Names

CTDSP2; CTD Small Phosphatase 2; SCP2; OS4; Nuclear LIM Interactor-Interacting Factor 2; NLI-Interacting Factor 2; Small CTD Phosphatase 2; PSR2; CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2; Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 2; Conserved Gene Amplified In Osteosarcoma; Small C-Terminal Domain Phosphatase 2; Protein OS-4; EC 3.1.3.16; NIF

Raised in

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human CTDSP2 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

Mouse IgG1

Clone No.

2D11

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Form

Liquid

Tested Applications

ELISA, WB, FC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2500
FC	1:100-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Flow Cytometry (FC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.

Gene References into Functions

CTDSP2 induces p21(Cip1/Waf1) through increasing the activity of Ras. PMID: 25990325
These results suggest that SCP2 is involved in promoter clearance during steroid-activated transcription. PMID: 16724108
SCP2 acts as a phosphatase for regulatory phosphorylations in the linker region of Smad1 and Smad2 PMID: 17085434

Subcellular Location

Nucleus.

Tissue Specificity

Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver.

Database Links

HGNC: 17077

OMIM: 608711

KEGG: hsa:10106

STRING: 9606.ENSP00000381148

UniGene: Hs.524530

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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