CTDSP2 Antibody

Code CSB-PA006143GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
CTDSP2
Alternative Names
Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 2 antibody; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 antibody; conserved gene amplified in osteosarcoma 4 antibody; conserved gene amplified in osteosarcoma antibody; CTDS2_HUMAN antibody; Ctdsp2 antibody; NIF2 antibody; NLI interacting factor 2 antibody; NLI-interacting factor 2 antibody; Nuclear LIM interactor interacting factor 2 antibody; Nuclear LIM interactor-interacting factor 2 antibody; OS4 antibody; Protein OS 4 antibody; Protein OS-4 antibody; PSR2 antibody; SCP2 antibody; Small C-terminal domain phosphatase 2 antibody; Small CTD phosphatase 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human CTDSP2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
Gene References into Functions
  1. CTDSP2 induces p21(Cip1/Waf1) through increasing the activity of Ras. PMID: 25990325
  2. These results suggest that SCP2 is involved in promoter clearance during steroid-activated transcription. PMID: 16724108
  3. SCP2 acts as a phosphatase for regulatory phosphorylations in the linker region of Smad1 and Smad2 PMID: 17085434
Subcellular Location
Nucleus.
Tissue Specificity
Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver.
Database Links

HGNC: 17077

OMIM: 608711

KEGG: hsa:10106

STRING: 9606.ENSP00000381148

UniGene: Hs.524530

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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