MSH6 Monoclonal Antibody

Datasheet
Code CSB-MA0150321A0m
Product Type Monoclonal Antibody
Size US$350Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P52701
Image
  • Immunohistochemical of paraffin-embedded Human lung cancer tissue using CSB-MA0150321A0m at dilution of 1:200.

Immunogen Recombinant Human MSH6 Protein
Raised in mouse
Species Reactivity Human
Specificity specific for human Msh6 denatured and native forms.
Tested Applications ELISA,IHC;Recommended dilution:IHC:1:50-1:500
Relevance This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa,called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have beendescribed.
Form liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%,protein G purifed
Clonality monoclonal
Alias MutS Homolog 6 GTBP HSAP2 DNA Mismatch Repair Protein Msh6 G/T Mismatch-Binding Protein
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Gene Names MSH6
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Clone No. 2C12F3
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Function Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch
Involvement in disease Hereditary non-polyposis colorectal cancer 5 (HNPCC5); Endometrial cancer (ENDMC); Mismatch repair cancer syndrome (MMRCS); Colorectal cancer (CRC)
Subcellular Location Nucleus, Chromosome
Protein Families DNA mismatch repair MutS family
Database Links

HGNC: 7329

OMIM: 114500

KEGG: hsa:2956

STRING: 9606.ENSP00000234420

UniGene: Hs.445052

Pathway DNA repair pathway

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