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The OCT4 Monoclonal Antibody is formed by introducing Recombinant Human POU Domain, Class 5, Transcription Factor 1 Protein (1-360AA) in mice. It is an IgG2b subtype antibody that reacts with Human, Mouse, Rat OCT4, a POU transcription factor.
OCT4 is expressed in embryonic stem cells. In these stem cells, it controls the expression of genes that facilitate proliferation. At certain levels, OCT4 alongside Sox2 facilitates the renewal and maintains the pluripotency of stem cells. A fall or rise in OCT4 will activate genes that trigger the differentiation of these germ cells.
Abnormal expression of OCT4 is known to play a role in the embryogenesis and proliferation of cancer cells. The OCT4 Antibody binds to OCT4 in cancer cells. Thus, it can be used for detecting OCT4 and for studying anti-OCT4 options.
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