Recombinant Human Carbonic anhydrase 7(CA7) (Active)

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Code CSB-AP005411HU
Size US$3267Purchase it in Cusabio online store
(only available for customers from the US)
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity The esterase activity is determined to be greater than 1000 pmol/min/ug
Target Names CA7
Uniprot No. P43166
Research Area Cell Biology
Alternative Names CA 7; CA VII; CA-VII; Ca7; CAH7_HUMAN; Carbonate dehydratase VII; Carbonic anhydrase 7; Carbonic anhydrase VII; Carbonic dehydratase VII; CAVII; EC=4.2.1.1
Species Homo sapiens (Human)
Source E.coli
Expression Region 1-264aa
Complete Sequence MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
Mol. Weight 30.72 kDa
Protein Length Full Length
Tag Info C-terminal 6xHis-tagged
Form Liquid
Buffer 0.2 μm filtered 20 mM Tris-HCl, 150 mM NaCl, pH 8.0
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Data

Function Reversible hydration of carbon dioxide.
Gene References into Functions
  1. Our results indicate that decreased expression of CA7 correlates with disease progression and predicts poor prognosis in CRC, especially for patients with early stage tumors. PMID: 25885898
  2. native hCA VII can protect cells from oxidative damage by preventing the apoptosis cascade and that cysteines play a leading role in this process PMID: 23851572
  3. conclude that the full-length CA VII is a predominant active form in human brain and also in other tissues. In addition to the brain, CA VII is expressed in several other organs including the stomach, duodenum, colon, liver, and skeletal muscle PMID: 20493921
  4. GABAergic transmission is influenced by the neuronal expression of carbonic anhydrase cavii--REVIEW PMID: 15528236
  5. these data furnish further evidence that hCA VII is the isozyme responsible for the anticonvulsant/antiepileptic activity of sulfonamides and sulfamates PMID: 15686895

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Subcellular Location Cytoplasm
Protein Families Alpha-carbonic anhydrase family
Database Links

HGNC: 1381

OMIM: 114770

KEGG: hsa:766

STRING: 9606.ENSP00000345659

UniGene: Hs.37014

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