Recombinant Human Desert hedgehog protein(DHH),partial (Active)

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Code CSB-AP000411HU
Product Type Other
Size US$112Purchase it in Cusabio online store
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Uniprot No. O43323
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered 10mM PB, pH 6.0, 300mM NaCl ,lyophilized
Alias DHH
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by its ability to induce alkaline phosphatase production by C3H10T1/2(CCL-226) cells is 15-45 μg/ml.
Purity >96% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence II+GPGRGPVG RRRYARKQLV PLLYKQFVPG VPERTLGASG PAEGRVARGS ERFRDLVPNY NPDIIFKDEE NSGADRLMTE RCKERVNALA IAVMNMWPGV RLRVTEGWDE DGHHAQDSLH YEGRALDITT SDRDRNKYGL LARLAVEAGF DWVYYESRNH VHVSVKADNS LAVRAGG
Research Area Stem Cells?
Source E.coli
Gene Names DHH
Expression Region 24-198aa
Tag Info Tag-Free
Mol. Weight 19.9 kDa
Protein Description Partial
PubMed ID 15489334; 11017805; 19561611; 20519495; 15356051
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Function Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.
Involvement in disease Partial gonadal dysgenesis with minifascicular neuropathy 46,XY (PGD); 46,XY sex reversal 7 (SRXY7)
Subcellular Location Desert hedgehog protein N-product: Cell membrane, Lipid-anchor, Extracellular side, Note=The N-terminal peptide remains associated with the cell surface, SUBCELLULAR LOCATION: Desert hedgehog protein C-product: Secreted, extracellular space
Protein Families Hedgehog family
Database Links

HGNC: 2865

OMIM: 233420

KEGG: hsa:50846

STRING: 9606.ENSP00000266991

UniGene: Hs.524382

Pathway Hedgehog signaling pathway

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