Recombinant Rat Cardiotrophin-1 protein(Ctf1) (Active)

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Code CSB-AP000211RA
Product Type Other
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Uniprot No. Q63086
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered 20 mM PB, pH 7.4, 150mM NaCl ,lyophilized
Alias CT-1
Species Rattus norvegicus (Rat)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0x106 IU/mg.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence MSQREGSLED HQTDSSFSFL PHLEAKIRQT HNLARLLTKY ADQLLEEYVQ QQGEPFGLPG FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSALPAL LDAVRRRQAE LNPRAPRLLR SLEDAARQVR ALGAAVETVL AALGAAARGP VPEPVATSAL FTSNSAAGVF SAKVLGLHVC GLYGEWVSRT EGDLGQLVPG GVA
Research Area Immunology
Source E.coli
Gene Names Ctf1
Expression Region 1-203aa
Tag Info Tag-Free
Mol. Weight 21.4 kDa
Protein Description Full Length
PubMed ID 8604995; 15489334
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Function Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
Subcellular Location Secreted
Protein Families IL-6 superfamily
Tissue Specificity Expressed in the ventricle and atrium of adult rats. Also detected in the lung, kidney, liver, skeletal muscle, stomach and urinary bladder. Not detected in brain, colon, testis, spleen or thymus. Overexpressed in the ventricles in the case of hypertensio
Database Links

KEGG: rno:29201

STRING: 10116.ENSRNOP00000025646

UniGene: Rn.10253

Pathway Jak-STAT signaling pathway

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