Recombinant Rat Cardiotrophin-1 protein(Ctf1) (Active)

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Code CSB-AP000211RA
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Product Details

Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0x106 IU/mg.
Target Names Ctf1
Uniprot No. Q63086
Research Area Immunology
Alternative Names Ctf1Cardiotrophin-1; CT-1
Species Rattus norvegicus (Rat)
Source E.coli
Expression Region 1-203aa
Mol. Weight 21.4 kDa
Protein Length Full Length
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 150mM NaCl
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time 5-10 business days
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Background

(From Uniprot)
Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
Gene References into Functions
  1. Cardiotrophin-1 modulates glucose transport in cardiomyocytes positively or negatively depending on its concentration. PMID: 23277190
  2. Cardiomyocytes treated with CT-1 present high spontaneous Ca(2+) release during diastole, a mechanism linked to arrhythmogenicity in the pathologic heart. PMID: 22787135
  3. Cardiotrophin 1 is involved in cardiac, vascular, and renal fibrosis and dysfunction. PMID: 22733458
  4. Data suggest a key role for CT-1 in cardiac remodeling induced by aldosterone independent of changes in blood pressure levels. PMID: 21926338
  5. CT-1 induces VSMCs proliferation, hypertrophy and extracellular matrix production, and is upregulated in hypertension and by aldosterone. CT-1 may represent a new target of vascular wall remodeling in hypertension PMID: 20216087
  6. Cardiotrophin-1 promotes the outgrowth of embryonic cranial motor neurons in isolated stage E12 hindbrain explants. PMID: 11932952
  7. CT1 has a role in hypertrophy of rat cardiomyocytes as measured by an increase in cell area and enhanced protein: DNA ratio PMID: 12027405
  8. Ctf1 has a possible role in post-MI wound healing PMID: 14674704
  9. hypertrophic responses to cardiotrophin-1 is mitogen activated protein kinase kinase 5-mitogen-activated protein kinase 7 pathway PMID: 15623435
  10. Motoneurons retrogradely transport from the tongue radiolabeled GDNF, BDNF, and cardiotrophin-1; cardiotrophin-1 follows a strict degradation pathway after retrograde transport to the soma. PMID: 15659589
  11. CT-1 can affect the expression of GATA4 mRNA and the binding activity of cardiac myocytes PMID: 19327894
  12. CT-1 signals through p38, ERK, and Akt in a parallel manner to activate NF-kappa B and that NF-kappa B is required for CT-1 to mediate its full cytoprotective effects in cardiac myocytes. PMID: 11448959

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Subcellular Location Secreted
Protein Families IL-6 superfamily
Tissue Specificity Expressed in the ventricle and atrium of adult rats. Also detected in the lung, kidney, liver, skeletal muscle, stomach and urinary bladder. Not detected in brain, colon, testis, spleen or thymus. Overexpressed in the ventricles in the case of hypertensio
Database Links

KEGG: rno:29201

STRING: 10116.ENSRNOP00000025646

UniGene: Rn.10253


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