ABCA8 Antibody

Code CSB-PA847031
Size US$297 How to order?
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  • Western blot analysis of extracts from HUVEC cells, using ABCA8 antibody.
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ABCA8 Polyclonal antibody
Uniprot No. O94911
Target Names ABCA8
Alternative Names ABCA8 antibody; KIAA0822ATP-binding cassette sub-family A member 8 antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from internal of Human ABCA8.
Immunogen Species Homo sapiens (Human)
Clonality Polyclonal
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate. In vitro, also imports ochratoxin A. Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes.; Catalyzes ATP-dependent efflux of cholesterol and taurocholate. Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels.
Gene References into Functions
  1. ABCA8 facilitates cholesterol efflux and modulates HDL-cholesterol levels. PMID: 28882873
  2. Genes ABCC7, A3, A8, A12, and C8 prevailed among the most upregulated or downregulated ones. In conclusion, the results supported our theory about general adenosine triphosphate-binding cassette gene expression profiles and their importance for cancer on clinical as well as research levels PMID: 28468577
  3. These data suggest a direct relationship between the levels of ABCA8 and the ectopic expression of alpha-syn and increased expression of p25alpha PMID: 23948991
  4. ABCA8 is highly expressed in human brain and regulates lipid metabolism in oligodendrocytes, potentially playing a role in myelin formation and maintenance. PMID: 23560799
  5. SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels PMID: 21707071
  6. Functional analysis of the transport properties of ABCA8. PMID: 12379217

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Subcellular Location Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.
Protein Families ABC transporter superfamily, ABCA family
Tissue Specificity Widely expressed with higher expression in heart, skeletal muscle and liver. Highly expressed in the superior frontal white matter and inferior temporal white matter.
Database Links

HGNC: 38

OMIM: 612505

KEGG: hsa:10351

STRING: 9606.ENSP00000269080

UniGene: Hs.58351

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