ABCA8 Antibody

Code CSB-PA000781
Size US$100
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  • Western Blot analysis of HuvEc cells using ABCA8 Polyclonal Antibody
  • Western Blot analysis of HuvEc PC12 cells using ABCA8 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
Alternative Names
ABCA8 antibody; KIAA0822ATP-binding cassette sub-family A member 8 antibody
Raised in
Species Reactivity
Synthesized peptide derived from the Internal region of Human ABCA8.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate. In vitro, also imports ochratoxin A. Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes.; Catalyzes ATP-dependent efflux of cholesterol and taurocholate. Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels.
Gene References into Functions
  1. ABCA8 facilitates cholesterol efflux and modulates HDL-cholesterol levels. PMID: 28882873
  2. Genes ABCC7, A3, A8, A12, and C8 prevailed among the most upregulated or downregulated ones. In conclusion, the results supported our theory about general adenosine triphosphate-binding cassette gene expression profiles and their importance for cancer on clinical as well as research levels PMID: 28468577
  3. These data suggest a direct relationship between the levels of ABCA8 and the ectopic expression of alpha-syn and increased expression of p25alpha PMID: 23948991
  4. ABCA8 is highly expressed in human brain and regulates lipid metabolism in oligodendrocytes, potentially playing a role in myelin formation and maintenance. PMID: 23560799
  5. SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels PMID: 21707071
  6. Functional analysis of the transport properties of ABCA8. PMID: 12379217

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Subcellular Location
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.
Protein Families
ABC transporter superfamily, ABCA family
Tissue Specificity
Widely expressed with higher expression in heart, skeletal muscle and liver. Highly expressed in the superior frontal white matter and inferior temporal white matter.
Database Links

HGNC: 38

OMIM: 612505

KEGG: hsa:10351

STRING: 9606.ENSP00000269080

UniGene: Hs.58351

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