ABCC2 Antibody

Datasheet
Code CSB-PA852918LA01HU
See More Details Free Antibody trial simple
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Uniprot No. Q92887
Image
  • IHC image of CSB-PA873704LA01HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescent analysis of A549 cells using CSB-PA852918LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Immunogen Recombinant Human Canalicular multispecific organic anion transporter 1 protein (724-947AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200
Relevance Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2) (Canalicular multidrug resistance protein) (Multidrug resistance-associated protein 2), ABCC2, CMOAT CMOAT1 CMRP MRP2
Immunogen Species Human
Research Area Signal Transduction
Target Names ABCC2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Involvement in disease Dubin-Johnson syndrome (DJS)
Subcellular Location Apical cell membrane, Multi-pass membrane protein
Protein Families ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Tissue Specificity Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.
Database Links

HGNC: 53

OMIM: 237500

KEGG: hsa:1244

STRING: 9606.ENSP00000359478

UniGene: Hs.368243

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