ABCC8 Antibody

Datasheet
Code CSB-PA22439A0Rb
See More Details
Size US$299
Uniprot No. Q09428
Image
  • IHC image of CSB-PA22439A0Rb diluted at 1:500 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of U251 cells with CSB-PA22439A0Rb at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunogen Recombinant Human ATP-binding cassette sub-family C member 8 protein (729-838AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC, IF; Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200
Relevance Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1), ABCC8, HRINS SUR SUR1
Immunogen Species Human
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Research Area Signal Transduction
Target Names ABCC8
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release.
Involvement in disease Leucine-induced hypoglycemia (LIH); Familial hyperinsulinemic hypoglycemia 1 (HHF1); Diabetes mellitus, permanent neonatal (PNDM); Transient neonatal diabetes mellitus 2 (TNDM2)
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Database Links

HGNC: 59

OMIM: 240800

KEGG: hsa:6833

STRING: 9606.ENSP00000374467

UniGene: Hs.54470

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