ACSF3 Antibody

Code CSB-PA674579LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA674579LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA674579LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ACSF3 Polyclonal antibody
Uniprot No.
Target Names
ACSF3
Alternative Names
ACSF3 antibody; PSEC0197Malonate--CoA ligase ACSF3 antibody; mitochondrial antibody; EC 6.2.1.n3 antibody; Acyl-CoA synthetase family member 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Acyl-CoA synthetase family member 3, mitochondrial protein (365-484AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ACSF3 Antibody (Product code: CSB-PA674579LA01HU) is Non-conjugated. For ACSF3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA674579LB01HU ACSF3 Antibody, HRP conjugated ELISA
FITC CSB-PA674579LC01HU ACSF3 Antibody, FITC conjugated
Biotin CSB-PA674579LD01HU ACSF3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.
Gene References into Functions
  1. an essential role for ACSF3 in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism PMID: 28479296
  2. ACSF3 was significantly upregulated, and was involved in fatty acid and lipid metabolism and accelerated liver injury in alcoholic liver disease. PMID: 23337955
  3. data indicate that the CBFA2T3/ACSF3 locus is a novel recurrent oncogenic target of immunoglobulin heavy chain translocations, which might contribute to the pathogenesis of pediatric GC-derived B-cell lymphoma. PMID: 22420028
  4. ACSF3 is a candidate gene for non-classical CMAMMA observed in our patients. PMID: 21785126
  5. Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis. PMID: 21846720
  6. mutations in ACSF3, encoding a putative methylmalonyl-CoA and malonyl-CoA synthetase, were identified as a cause of combined malonic and methylmalonic aciduria. PMID: 21841779

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Involvement in disease
Combined malonic and methylmalonic aciduria (CMAMMA)
Subcellular Location
Mitochondrion.
Protein Families
ATP-dependent AMP-binding enzyme family
Database Links

HGNC: 27288

OMIM: 614245

KEGG: hsa:197322

STRING: 9606.ENSP00000320646

UniGene: Hs.461727

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