ACSF3 Antibody

Code CSB-PA674579LA01HU
Size US$299 How to order?
  • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA674579LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA674579LA01HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ACSF3 Polyclonal antibody
Uniprot No. Q4G176
Target Names ACSF3
Alternative Names ACSF3 antibody; PSEC0197Malonate--CoA ligase ACSF3 antibody; mitochondrial antibody; EC 6.2.1.n3 antibody; Acyl-CoA synthetase family member 3 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Acyl-CoA synthetase family member 3, mitochondrial protein (365-484AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The ACSF3 Antibody (Product code: CSB-PA674579LA01HU) is Non-conjugated. For ACSF3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA674579LB01HU ACSF3 Antibody, HRP conjugated ELISA
FITC CSB-PA674579LC01HU ACSF3 Antibody, FITC conjugated
Biotin CSB-PA674579LD01HU ACSF3 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.
Gene References into Functions
  1. an essential role for ACSF3 in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism PMID: 28479296
  2. ACSF3 was significantly upregulated, and was involved in fatty acid and lipid metabolism and accelerated liver injury in alcoholic liver disease. PMID: 23337955
  3. data indicate that the CBFA2T3/ACSF3 locus is a novel recurrent oncogenic target of immunoglobulin heavy chain translocations, which might contribute to the pathogenesis of pediatric GC-derived B-cell lymphoma. PMID: 22420028
  4. ACSF3 is a candidate gene for non-classical CMAMMA observed in our patients. PMID: 21785126
  5. Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis. PMID: 21846720
  6. mutations in ACSF3, encoding a putative methylmalonyl-CoA and malonyl-CoA synthetase, were identified as a cause of combined malonic and methylmalonic aciduria. PMID: 21841779

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Involvement in disease Combined malonic and methylmalonic aciduria (CMAMMA)
Subcellular Location Mitochondrion.
Protein Families ATP-dependent AMP-binding enzyme family
Database Links

HGNC: 27288

OMIM: 614245

KEGG: hsa:197322

STRING: 9606.ENSP00000320646

UniGene: Hs.461727

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