ACSF3 Antibody

Code CSB-PA674579LA01HU
Size US$299 How to order?
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  • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA674579LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA674579LA01HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ACSF3 Polyclonal antibody
Uniprot No. Q4G176
Target Names ACSF3
Alternative Names ACSF3 antibody; PSEC0197Malonate--CoA ligase ACSF3 antibody; mitochondrial antibody; EC 6.2.1.n3 antibody; Acyl-CoA synthetase family member 3 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Acyl-CoA synthetase family member 3, mitochondrial protein (365-484AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The ACSF3 Antibody (Product code: CSB-PA674579LA01HU) is Non-conjugated. For ACSF3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA674579LB01HU ACSF3 Antibody, HRP conjugated ELISA
FITC CSB-PA674579LC01HU ACSF3 Antibody, FITC conjugated
Biotin CSB-PA674579LD01HU ACSF3 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.
Gene References into Functions
  1. an essential role for ACSF3 in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism PMID: 28479296
  2. ACSF3 was significantly upregulated, and was involved in fatty acid and lipid metabolism and accelerated liver injury in alcoholic liver disease. PMID: 23337955
  3. data indicate that the CBFA2T3/ACSF3 locus is a novel recurrent oncogenic target of immunoglobulin heavy chain translocations, which might contribute to the pathogenesis of pediatric GC-derived B-cell lymphoma. PMID: 22420028
  4. ACSF3 is a candidate gene for non-classical CMAMMA observed in our patients. PMID: 21785126
  5. Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis. PMID: 21846720
  6. mutations in ACSF3, encoding a putative methylmalonyl-CoA and malonyl-CoA synthetase, were identified as a cause of combined malonic and methylmalonic aciduria. PMID: 21841779

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Involvement in disease Combined malonic and methylmalonic aciduria (CMAMMA)
Subcellular Location Mitochondrion.
Protein Families ATP-dependent AMP-binding enzyme family
Database Links

HGNC: 27288

OMIM: 614245

KEGG: hsa:197322

STRING: 9606.ENSP00000320646

UniGene: Hs.461727

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