ACYP2 Antibody, HRP conjugated

1. the genetic polymorphisms of ACYP2 and TSPYL6 are associated with increased risk of developing ischemic stroke PMID: 27686078
2. Results found an association between the ACYP2 rs1872328 polymorphism and cisplatin-induced ototoxicity. PMID: 28445188
3. Our results indicate that ACYP2 polymorphisms may influence the GC risk and may serve as a new precursory biomarker in the northwest Chinese Han population. PMID: 28415712
4. Findings indicate significant associations between single nucleotide oolymorphism (SNPs) in the acylphosphatase 2 (ACYP2) gene and breast cancer (BC) risk in a Han Chinese population. PMID: 27894080
5. ACYP2 gene may be associated with an increased risk of esophageal carcinoma in Chinese Han populations. Future studies to address the biological function of this polymorphism in the development of esophageal carcinoma are warranted. PMID: 28424424
6. three SNPs in ACYP2 (rs1682111, rs11896604 and rs843720) associate with lung cancer in the Chinese Han population. PMID: 27974682
7. Genetic polymorphisms in the telomere length-related gene ACYP2 are associated with the risk of colorectal cancer in a Chinese Han population. PMID: 28039478
8. Data show that the acylphosphatase 2 (ACYP2) gene polymorphism significantly decreased the risk of high altitude pulmonary edema (HAPE). PMID: 27552709
9. Rs6713088, rs843752, and rs17045754 associated with high-altitude pulmonary edema risk PMID: 28353602
10. Results shown that the previously reported association of an ACYP2 variant with cisplatin-induced hearing loss in pediatric brain tumor patients could be replicated in an independent cohort of patients with osteosarcoma. Therefor, the ACYP2 variant should be considered a predictor of cisplatin-induced hearing loss in patients with osteosarcoma or other solid tumors PMID: 26928270
11. These findings suggest a minor role of the single nucleotide polymorphisms of ACYP2 investigated as genetic determinants of chronic oxaliplatin-induced peripheral neurotoxicity. PMID: 25858589
12. The ACYP2 risk variant strongly predisposed these patients to precipitous hearing loss and was related to ototoxicity severity. PMID: 25665007
13. Enhanced stability is observed upon modifications of a loop region in the enzyme acylphosphatase and is achieved despite significant enthalpy losses. PMID: 23754389
14. The study used a stopped-flow device coupled to turbidometry detection to monitor the rapid conversion of human muscle acylphosphatase into oligomers with varying heparan sulfate and protein concentrations. PMID: 22522822
15. Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. PMID: 10542090
16. effects of 40 single point mutations on the conversion of the denatured form of the alpha/beta protein acylphosphatase (AcP) into insoluble aggregates PMID: 11799398
17. studies of aggregates formed from human muscle acylphosphatase and disaggregation suggests that amyloid formation occurs in discrete steps whose reversibility is increasingly difficult, and dependent on the size of the aggregates PMID: 15670608
18. Most of the conserved glycine residues in this protein could have been maintained during evolution because of their ability to inhibit amyloid aggregation. PMID: 16084386
19. extensive mutational analysis of aggregation and disaggregation of amyloid-like protofibrils of muscle acylphosphatase PMID: 18809411

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HGNC: 180

OMIM: 102595

KEGG: hsa:98

STRING: 9606.ENSP00000378161

UniGene: Hs.516173