ADAM28 Antibody

1. Within placental villi, ADAM28 mRNA levels were highest in HLA-G(+) column trophoblasts, and consistent with this, ADAM28 was preferentially localized to HLA-G(+) trophoblasts within distal anchoring columns and decidual tissue. PMID: 28623976
2. There is a relationship between the serum level of ADAM28 and the degree of the colonic cancer clinical stage. PMID: 29254295
3. miR-552 is an oncomir able to promote CRC metastasis in part through a mechanism of targeting ADAM28. PMID: 27661126
4. The data demonstrate that ADAM28 is expressed by epithelial cells of several normal organs, and suggest that ADAM28 plays a role in cell survival by suppression of C1q-induced cytotoxicity in bronchial epithelial cells. PMID: 26918856
5. ADAM28 is overexpressed in primary human prostate tumor biopsies, and it promotes human prostate cancer cell proliferation and migration. PMID: 27749584
6. The results of this study suggest that these proteins play important roles in pulmonary inflammatory reactions elicited against etiological viral agents. PMID: 25453333
7. Src is an inducer of ADAM28 gene expression through the MEK/extracellular signal-regulated kinase and PI3K/mammalian target of rapamycin pathways. PMID: 24007880
8. IL-1beta-induced MMP-13 expression and changes in cell proliferation and apoptosis in alpha7(+)hSMSC-OB cells are regulated by ADAM-28. PMID: 24613731
9. Sequence analysis of ADAM28 genes did not reveal any putative mutations for hyperostosis cranialis interna to chromosome 8p21 PMID: 23640157
10. The change of ADAM28 and IGFBP-3 gene expression is present in the normal tissue in overweight/obese patients with colorectal cancer only, and the observed variability of ADAM28 and IGFBP-3 expression may be an initial process of cancer proliferation PMID: 23527725
11. High ADAM28 expression is associated with B-Cell Chronic Lymphocytic Leukemia. PMID: 23643150
12. Human ADAM28 expression levels were positively correlated with parameters of the metabolic syndrome. PMID: 23010875
13. ADAM28 cleaves and inactivates proapoptotic VWF in carcinoma cells and enhances lung metastasis probably by promoting carcinoma cell survival within the blood vessels. PMID: 22636800
14. Study shows using proteomics that ADAM28 may be used as a possible biomarker of bladder cancer. PMID: 21913264
15. ADAM28 showed significant differences compared with normal individuals, so it may be a biomarker of bladder cancer. PMID: 21782798
16. ADAM28 might actively participate in manipulating the proliferation, differentiation, and apoptosis of human dental pulp stem cells (HDPSCs). PMID: 21329817
17. It plays a role in cancer cell proliferation, invasion and metastasis. (review) PMID: 21077327
18. These data provide the first evidence that CTGF is a novel substrate of ADAM28 and suggest that ADAM28 may promote VEGF(165)-induced angiogenesis in the breast carcinomas by the CTGF digestion in the CTGF/VEGF(165) complex. PMID: 20971063
19. High ADAM28 in serum is associated with non-small-cell lung cancers. PMID: 20112342
20. Upregulation of ADAM28 is associated with asbestos-related lung adenocarcinomas. PMID: 20544843
21. was able to effectively manipulate the proliferation, apoptosis, and differentiation of human periodontal ligament stem cells PMID: 20450360
22. overexpression of A disintegrin and metalloproteinase 28 was increased according to its histologic grade in conventional chondrosarcoma and could be one of the helpful tools in distinguishing between low-grade chondrosarcoma and enchondroma. PMID: 19896699
23. ADAM8, ADAM15, and ADAM28, but not ADAM17, catalyzed ectodomain shedding of CD23, the low affinity IgE receptor. PMID: 12777399
24. data demonstrate for the first time that ADAM28 is overexpressed and activated in human non-small cell lung carcinomas, and suggest the possibility that ADAM28 plays a role in cell proliferation and progression of the human lung carcinomas PMID: 16052521
25. ADAM28 is overexpressed in an activated form in breast carcinoma cells and suggest ADAM28 is involved in cell proliferation through enhanced bioavailability of IGF-I released from the IGF-I/IGFBP-3 complex by IGFBP-3 cleavage in breast carcinomas. PMID: 17047053
26. ADAM28s promotes PSGL-1/P-selectin-mediated leukocyte rolling adhesion to endothelial cells and subsequent infiltration into tissue spaces through interaction with PSGL-1 PMID: 17597069
27. Report essential role of ADAM28 in regulating the proliferation and differentiation of human dental papilla mesenchymal cells. PMID: 18690470
28. These results indicate that ADAM28 participates in proteoglycan degradation. PMID: 19527685

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HGNC: 206

OMIM: 606188

KEGG: hsa:10863

STRING: 9606.ENSP00000265769

UniGene: Hs.174030