ADAMTS15 Antibody

Datasheet

Code	CSB-PA837445LA01HU
Size	US$166
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Image	IHC image of CSB-PA837445LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ADAMTS15 Polyclonal antibody

Uniprot No.

Q8TE58

Target Names

ADAMTS15

Alternative Names

A disintegrin and metalloproteinase with thrombospondin motifs 15 antibody; A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 15 antibody; A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 15 preproprotein antibody; A disintegrin like and metalloprotease with thrombospondin type 1 motif 15 antibody; A disintegrin like and metalloprotease with thrombospondin type 1 motif 15 preproprotein antibody; ADAM metallopeptidase with thrombospondin type 1 motif 15 antibody; ADAM TS 15 antibody; ADAM TS15 antibody; ADAM-TS 15 antibody; ADAM-TS15 antibody; ADAMTS 15 antibody; ADAMTS-15 antibody; ADAMTS15 antibody; ATS15_HUMAN antibody; MGC126403 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 15 protein (801-913AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ADAMTS15 Antibody (Product code: CSB-PA837445LA01HU) is Non-conjugated. For ADAMTS15 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA837445LB01HU	ADAMTS15 Antibody, HRP conjugated	ELISA
FITC	CSB-PA837445LC01HU	ADAMTS15 Antibody, FITC conjugated
Biotin	CSB-PA837445LD01HU	ADAMTS15 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.

Gene References into Functions

ADAMTS4 and ADAMTS15 were upregulated in symptomatic uterine leiomyomas. PMID: 28323982
ADAMTS15 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
ADAMTS15 is a candidate gene for intracranial aneurysms PMID: 25649796
ADAMTS-15 has multiple actions on tumor pathophysiology including modulation of cell-extracellular matrix interactions, which likely involve syndecan-4. PMID: 25099234
Versican processing by ADAMTS5 and ADAMTS15 contribute to muscle fiber formation. PMID: 23233679
ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene PMID: 20590445
ADAMTS8 and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma PMID: 16152618
ADAMTS15 may be target of inactivating mutations in human cancer. PMID: 19458070

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Subcellular Location

Secreted, extracellular space, extracellular matrix. Cell surface.

Tissue Specificity

Expressed in fetal liver and kidney, but not in any of the adult tissues examined.

Database Links

HGNC: 16305

OMIM: 607509

KEGG: hsa:170689

STRING: 9606.ENSP00000299164

UniGene: Hs.534221

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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