ADGRG1 Antibody

1. High GPR56 expression is associated with metastasis via epithelialmesenchymal transition carcinoma in colorectal cancer. PMID: 30066935
2. The authors conclude that soluble GPR56 is present in vivo and is elevated in certain chronic inflammatory diseases such as rheumatoid arthritis. Hence, soluble GPR56 might be considered a potential biomarker for rheumatoid arthritis disease progression. PMID: 28690029
3. Our data suggest that collagen III may be effective in optimising islet function to improve islet transplantation outcomes, and GPR56 may be a target for the treatment of type 2 diabetes PMID: 29855662
4. that GPR56 might be an inhibitor of the mesenchymal transition across multiple tumor types beyond glioblastoma PMID: 29166609
5. We report a clinical feature, electroclinical findings, and clinical course of a patient with a severe phenotype of MCPH2 including microcephaly, refractory infantile spasms and intellectual disability. We detected a new homozygous splicing variant c.3335+1G>C in the WD repeat domain 62 (WDR62) gene, and an additional new heterozygous missense mutation c.1706T>A of G protein-coupled receptor 56 (GPR56) gene PMID: 28756000
6. Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region. PMID: 28874577
7. Brain MRI in the affected siblings as well as in the two previously reported individuals with bi-allelic COL3A1 mutations showed a brain phenotype similar to that associated with mutations in GPR56. PMID: 28258187
8. GPR56 inhibits natural cytotoxicity of human NK cells. PMID: 27184850
9. Functional relevance of GPR56 expression was validated in mice, in which co-expression of Gpr56 significantly accelerated HOXA9-induced leukemogenesis PMID: 27063597
10. expression and activation of GPR56 may modulate melanoma progression in part by inducing IL-6 production after N-terminal fragment dissociation and C-terminal fragment self-activation PMID: 27818281
11. Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling PMID: 28424266
12. GPR56 regulates the proliferation and invasion capacity of osteosarcoma cells. PMID: 27396430
13. High GPR56 expression was significantly associated with high-risk genetic subgroups and poor outcome in patients with acute myeloid leukemia and identifies cancer stem cells with high repopulating potential. PMID: 26834243
14. Data suggest that agonist-induced signal transduction via either GPR56/ADGRG1 or BAI1/ADGRB1 does not require conserved membrane-proximal stalk region of these proteins; ADGRG1 may participate in stalk-dependent and stalk-independent signaling. PMID: 26710850
15. Agonistic antibodies reveal the function of GPR56 in human glioma U87-MG cells PMID: 25832639
16. we knocked down GPR56 in cardiomyocytes and found that GPR56 promoted Ang II-induced cardiomyocyte hypertrophy and it contributed to PCBP2 effects on cardiomyocyte hypertrophy PMID: 26116532
17. GPR56 and GPR110 are activated by exposure of a cryptic tethered agonist PMID: 25918380
18. These findings demonstrate that reduced expression of GPR56 in lung fibroblasts may be an important link with pulmonary fibrosis, playing a role in regulating some important fibroblast functions. PMID: 24742924
19. Data show that Gpr56, a G-coupled protein receptor, is required for hematopoietic cluster formation during transdifferentiation process in endothelial to hematopoietic cell transition (EHT). PMID: 25547674
20. these data reveal a mechanism by which control of GPR56 expression pattern by multiple alternative promoters can influence stem cell proliferation, gyral patterning, and, potentially, neocortex evolution. PMID: 24531968
21. GPR56, MT1G, and RASSF1 might be the potential methylation markers associated with acquired multidrug resistance of lung adenocarcinoma. PMID: 23902976
22. Loss of GPR56 is associated with abnormal muscle development. PMID: 24102982
23. GPR56 may represent an important GPCR for the maintenance of HSCs by acting as a co-ordinator of interactions with the BM osteosteal niche. PMID: 23478665
24. The present study confirms the phenotypic overlap between GPR56-related brain dysgenesis and other cobblestone-like syndromes. PMID: 23274687
25. Disease-associated mutations prevent GPR56-collagen III interaction. PMID: 22238662
26. study reports a novel missense mutation of GPR56, E496K, identified in a consanguineous pedigree with bilateral frontoparietal polymicrogyria PMID: 21723461
27. GPR56 expression is a common trait of human cytotoxic lymphocytes and might affect the migratory properties of these cells. PMID: 21724806
28. The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity. PMID: 21708946
29. consistent with its suppressive roles in melanoma progression, the expression levels of GPR56 are inversely correlated with the malignancy of melanomas in human subjects PMID: 21724588
30. GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms PMID: 21349848
31. Results suggest that the splicing of GPR56 may induce differential tumorigenic responses owing to their varied ability to activate transcription factors. PMID: 19572147
32. A significant correlation between GPR56, TG2, and NF-kappaB was observed that correlated with nodal metastasis and tumor invasion in esophageal squamous cell carcinoma. PMID: 20874003
33. Identify GPR56 as a novel marker capable of discriminating different natural killer cells subsets. PMID: 20008459
34. results show that mutations in GPR56 cause a human brain cortical malformatin called bilateral frontoparietal polymicrogyria (BFPP); data suggest that GPR56 signaling plays an essential role in regional development of human cerebral cortex PMID: 15044805
35. Increased expression of GPCR56 is associated with esophageal squamous cell carcinoma PMID: 15916848
36. Results show that GPR56 binds specifically to tissue transglutaminase, TG2, a widespread component of tissue and tumor stroma previously implicated as an inhibitor of tumor progression. PMID: 16757564
37. Review describes the expression of a ligand that interacts with GPR56 in metastatic melanoma cells as TG2, a major crosslinking enzyme in the tumor extracellular matrix. PMID: 17314516
38. These results define the biochemical properties of GPR56 protein, and suggest that the expression of GPR56 protein is suppressed in human pancreatic cancer cells. PMID: 17932623
39. We have shown that GPR56 GPS mutant protein is defective in cleavage and surface localization, while non-GPS mutant proteins are cleaved normally but still defective in surface localization. PMID: 18042463
40. This study reported that three consanguineous families in which four affected individuals with Bilateral frontoparietal polymicrogyria and GPR56 mutations had Lennox-Gastaut syndrome. PMID: 19016831
41. Our data suggest that GPR56 can be used as an NSC/NPC marker within the neural cell lineage, especially in combination with nestin. PMID: 19525879

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HGNC: 4512

OMIM: 604110

KEGG: hsa:9289

STRING: 9606.ENSP00000369018

UniGene: Hs.513633