ADK Antibody

Code CSB-PA346232LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: HL60 whole cell lysate, Rat kidney tissue, Rat liver tissue, Mouse kideny tissue, Mouse liver tissue
    All lanes: ADK antibody at 3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 41, 39, 35, 37 kDa
    Observed band size: 41 kDa

  • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA346232LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA346232LA01HU at dilution of 1:100

  • Immunofluorescent analysis of PC-3 cells using CSB-PA346232LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ADK Polyclonal antibody
Uniprot No.
Target Names
ADK
Alternative Names
2310026J05Rik antibody; 5033405D03Rik antibody; Adenosine 5''-phosphotransferase antibody; Adenosine kinase antibody; adk antibody; ADK_HUMAN antibody; AI255373 antibody; AI987814 antibody; AK antibody; MGC6593 antibody; OTTHUMP00000019864 antibody; OTTHUMP00000019865 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human Adenosine kinase protein (18-256AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ADK Antibody (Product code: CSB-PA346232LA01HU) is Non-conjugated. For ADK Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA346232LB01HU ADK Antibody, HRP conjugated ELISA
FITC CSB-PA346232LC01HU ADK Antibody, FITC conjugated
Biotin CSB-PA346232LD01HU ADK Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Gene References into Functions
  1. The results of this study showed that over-expression of the major adenosine removing enzyme ADK in reactive astrocytes and subpopulation of remaining neurons in Rasmussen Encephalitis patients plays an important role in the epileptogensis of Rasmussen Encephalitis. PMID: 28789481
  2. rs11001109 rare allele homozygosity is associated with increased risk of post-traumatic epilepsy development after brain injury. PMID: 26040919
  3. The results of this study suggest that upregulation of ADK is a common pathologic component of FCDIIB. PMID: 25575137
  4. These results suggest that upregulation of ADK is a common pathologic hallmark of Rasmussen encephalitis and that ADK might be a target in the treatment of epilepsy associated with Rasmussen encephalitis. PMID: 24128682
  5. Data show that we a significantly higher expression of ADK in the peritumoral infiltrated tissue of patients with epilepsy than in patients without epilepsy. PMID: 22092111
  6. The results of this study suggested that dysregulation of ADK in astrocytes is a common pathologic hallmark of temporal lobe epilepsy. PMID: 21635241
  7. The cytoplasmic isoform of adenosine kinase is sufficient to alter sleep physiology. ADK might orchestrate neurotransmitter pathways involved in the generation of electroencephlogram oscillations and regulation of sleep. PMID: 20881134
  8. The catalytic properties, gene expression and protein levels of certain proteins involved in mitochondrial ATP synthesis, such as F1F0-ATPase, ANT and AK, in human skin fibroblasts with trisomic karyotype, compared them with euploid fibroblasts. PMID: 20698827
  9. Equilibrative nucleoside transporters (hENT1, hENT2) together with adenosine kinase and 5'-nucleotidase play a crucial role in the regulation of CFTR through an adenosine-dependent pathway in human airway epithelia. PMID: 12820662
  10. role for HIF-1alpha in transcriptional repression of AK in hypoxia PMID: 18309031
  11. adenosine kinase gene expression was significantly higher in cancer than in normal-appearing tissue, in line with our previous measurements of adenosine kinase enzyme activities in colorectal tumor samples PMID: 18600536
  12. both deoxycytidine kinase and adenosine kinase are involved in this model of ADA deficiency PMID: 18600545
  13. This study reports for the first time subcellular localization of the enzyme AdK in mammalian cells. PMID: 19635462

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Involvement in disease
Hypermethioninemia due to adenosine kinase deficiency (HMAKD)
Subcellular Location
[Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
Protein Families
Carbohydrate kinase PfkB family
Tissue Specificity
Widely expressed. Highest level in placenta, liver, muscle and kidney.
Database Links

HGNC: 257

OMIM: 102750

KEGG: hsa:132

STRING: 9606.ENSP00000286621

UniGene: Hs.656586

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