ADK Antibody

1. The results of this study showed that over-expression of the major adenosine removing enzyme ADK in reactive astrocytes and subpopulation of remaining neurons in Rasmussen Encephalitis patients plays an important role in the epileptogensis of Rasmussen Encephalitis. PMID: 28789481
2. rs11001109 rare allele homozygosity is associated with increased risk of post-traumatic epilepsy development after brain injury. PMID: 26040919
3. The results of this study suggest that upregulation of ADK is a common pathologic component of FCDIIB. PMID: 25575137
4. These results suggest that upregulation of ADK is a common pathologic hallmark of Rasmussen encephalitis and that ADK might be a target in the treatment of epilepsy associated with Rasmussen encephalitis. PMID: 24128682
5. Data show that we a significantly higher expression of ADK in the peritumoral infiltrated tissue of patients with epilepsy than in patients without epilepsy. PMID: 22092111
6. The results of this study suggested that dysregulation of ADK in astrocytes is a common pathologic hallmark of temporal lobe epilepsy. PMID: 21635241
7. The cytoplasmic isoform of adenosine kinase is sufficient to alter sleep physiology. ADK might orchestrate neurotransmitter pathways involved in the generation of electroencephlogram oscillations and regulation of sleep. PMID: 20881134
8. The catalytic properties, gene expression and protein levels of certain proteins involved in mitochondrial ATP synthesis, such as F1F0-ATPase, ANT and AK, in human skin fibroblasts with trisomic karyotype, compared them with euploid fibroblasts. PMID: 20698827
9. Equilibrative nucleoside transporters (hENT1, hENT2) together with adenosine kinase and 5'-nucleotidase play a crucial role in the regulation of CFTR through an adenosine-dependent pathway in human airway epithelia. PMID: 12820662
10. role for HIF-1alpha in transcriptional repression of AK in hypoxia PMID: 18309031
11. adenosine kinase gene expression was significantly higher in cancer than in normal-appearing tissue, in line with our previous measurements of adenosine kinase enzyme activities in colorectal tumor samples PMID: 18600536
12. both deoxycytidine kinase and adenosine kinase are involved in this model of ADA deficiency PMID: 18600545
13. This study reports for the first time subcellular localization of the enzyme AdK in mammalian cells. PMID: 19635462

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HGNC: 257

OMIM: 102750

KEGG: hsa:132

STRING: 9606.ENSP00000286621

UniGene: Hs.656586