AEN Antibody

Code CSB-PA819883LA01HU
Size US$166
Order now
Image
  • Immunofluorescence staining of HepG2 cells with CSB-PA819883LA01HU at 1:530, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Alternative Names
Aen antibody; AEN_HUMAN antibody; apoptosis enhancing nuclease antibody; Apoptosis-enhancing nuclease antibody; Interferon stimulated exonuclease gene 20kDa like 1 antibody; Interferon stimulated exonuclease gene 20kDa like 1; isoform CRA_a antibody; Interferon-stimulated 20 kDa exonuclease-like 1 antibody; ISG20L1 antibody; pp12744 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Apoptosis-enhancing nuclease protein (117-325AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The AEN Antibody (Product code: CSB-PA819883LA01HU) is Non-conjugated. For AEN Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA819883LB01HU AEN Antibody, HRP conjugated ELISA
FITC CSB-PA819883LC01HU AEN Antibody, FITC conjugated
Biotin CSB-PA819883LD01HU AEN Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IF
Recommended Dilution
Application Recommended Dilution
IF 1:200-1:1000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.
Gene References into Functions
  1. identification of ISG20L1 as a p53 family target and discovery that modulation of this target can regulate autophagic processes further strengthens the connection between p53 signaling and autophagy PMID: 20429933
  2. AEN is an important downstream mediator of p53 in apoptosis induction in cancer. PMID: 18264133
Subcellular Location
Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.
Database Links

HGNC: 25722

OMIM: 610177

KEGG: hsa:64782

STRING: 9606.ENSP00000331944

UniGene: Hs.436102

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*