AGR3 Antibody

Datasheet

Code	CSB-PA286707
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA286707(AGR3 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA286707(AGR3 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-2: MCF7 cells, human colon tissue, Primary antibody: CSB-PA286707(AGR3 Antibody) at dilution 1/150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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Product Details
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Target Background

Product Details

Uniprot No.

Q8TD06

Target Names

AGR3

Alternative Names

AG-3 antibody; AG3 antibody; Agr3 antibody; AGR3_HUMAN antibody; Anterior gradient 3; xenopus; homolog of antibody; Anterior gradient homolog 3 antibody; Anterior gradient homolog 3 (Xenopus laevis) antibody; anterior gradient protein 3 antibody; Anterior gradient protein 3 homolog antibody; BCMP11 antibody; Breast cancer membrane protein 11 antibody; Gm888 antibody; hAG 3 antibody; hAG-3 antibody; HAG3 antibody; OTTHUMP00000158512 antibody; PDIA18 antibody; Protein disulfide isomerase family A member 18 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human AGR3

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:15-1:50

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.

Gene References into Functions

Results show that AGR3 was highly upregulated in low-grade serous carcinoma (LGSC) compared to high-grade serous carcinoma (HGSC). It can be use along with p53 for differential diagnosis of HGSC and LGSC. PMID: 29620196
transcriptionally activated in hepatitis C virus-infected cells by HCV NS5A PMID: 25868611
Data show the potential usability of anterior gradient homolog 3 (AGR3) and anterior gradient homolog 2 (AGR2) as biomarkers for blood-based early detection of breast cancer. PMID: 25875093
AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. PMID: 25751668
Relying on available data and in silico analyses, study shows that AGR2 and AGR3 proteins are co-expressed or uncoupled in context-dependent manners in diverse carcinomas and healthy tissues. PMID: 25666661
AGR3 was is predominantly expressed in liver cholangiocytes but not present in liver hepatocytes, making this protain a good marker for differential diagnosis of intrahepatic cholangiocarcinoma PMID: 24747240
AGR3 expression in ovarian cancer is independent of oestrogen-receptor expression. PMID: 22361111
AGR3 could serve as a prognostic marker for survival in patients with low grade and high grade serous ovarian carcinomas. PMID: 21451362
hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan [hAG-3 protein] PMID: 12592373
specific induction of Hag2 and Hag3 during hormone-induced breast carcinomas further support developmental specificity for the PDI/ERp family members PMID: 15935701

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Subcellular Location

Endoplasmic reticulum.

Protein Families

AGR family

Tissue Specificity

Expressed in the lung, in the ciliated cells of the airway epithelium. Expression increased with differentiation of airway epithelial cells. Not detected in the mucous cells. Expressed in ciliated cells in the oviduct. Also detected in stomach, colon, pro

Database Links

HGNC: 24167

OMIM: 609482

KEGG: hsa:155465

STRING: 9606.ENSP00000308606

UniGene: Hs.100686

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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