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AGR3 Antibody

Datasheet
Code CSB-PA286707
Size US$166
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Image
  • Immunohistochemistry (IHC) - AGR3 Antibody
    The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA286707(AGR3 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
  • Immunohistochemistry (IHC) - AGR3 Antibody
    The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA286707(AGR3 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
  • Western Blotting(WB) - AGR3 Antibody
    Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-2: MCF7 cells, human colon tissue, Primary antibody: CSB-PA286707(AGR3 Antibody) at dilution 1/150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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Product Details

Uniprot No.
Q8TD06
Target Names
AGR3
Alternative Names
AG-3 antibody; AG3 antibody; Agr3 antibody; AGR3_HUMAN antibody; Anterior gradient 3; xenopus; homolog of antibody; Anterior gradient homolog 3 antibody; Anterior gradient homolog 3 (Xenopus laevis) antibody; anterior gradient protein 3 antibody; Anterior gradient protein 3 homolog antibody; BCMP11 antibody; Breast cancer membrane protein 11 antibody; Gm888 antibody; hAG 3 antibody; hAG-3 antibody; HAG3 antibody; OTTHUMP00000158512 antibody; PDIA18 antibody; Protein disulfide isomerase family A member 18 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Fusion protein of Human AGR3
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
IHC 1:15-1:50
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.
Gene References into Functions
  1. Results show that AGR3 was highly upregulated in low-grade serous carcinoma (LGSC) compared to high-grade serous carcinoma (HGSC). It can be use along with p53 for differential diagnosis of HGSC and LGSC. PMID: 29620196
  2. transcriptionally activated in hepatitis C virus-infected cells by HCV NS5A PMID: 25868611
  3. Data show the potential usability of anterior gradient homolog 3 (AGR3) and anterior gradient homolog 2 (AGR2) as biomarkers for blood-based early detection of breast cancer. PMID: 25875093
  4. AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. PMID: 25751668
  5. Relying on available data and in silico analyses, study shows that AGR2 and AGR3 proteins are co-expressed or uncoupled in context-dependent manners in diverse carcinomas and healthy tissues. PMID: 25666661
  6. AGR3 was is predominantly expressed in liver cholangiocytes but not present in liver hepatocytes, making this protain a good marker for differential diagnosis of intrahepatic cholangiocarcinoma PMID: 24747240
  7. AGR3 expression in ovarian cancer is independent of oestrogen-receptor expression. PMID: 22361111
  8. AGR3 could serve as a prognostic marker for survival in patients with low grade and high grade serous ovarian carcinomas. PMID: 21451362
  9. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan [hAG-3 protein] PMID: 12592373
  10. specific induction of Hag2 and Hag3 during hormone-induced breast carcinomas further support developmental specificity for the PDI/ERp family members PMID: 15935701

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Subcellular Location
Endoplasmic reticulum.
Protein Families
AGR family
Tissue Specificity
Expressed in the lung, in the ciliated cells of the airway epithelium. Expression increased with differentiation of airway epithelial cells. Not detected in the mucous cells. Expressed in ciliated cells in the oviduct. Also detected in stomach, colon, pro
Database Links

HGNC: 24167

OMIM: 609482

KEGG: hsa:155465

STRING: 9606.ENSP00000308606

UniGene: Hs.100686

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