Name: AK2 Antibody
Brand: CUSABIO
SKU: CSB-PA001509GA01HU

Product Details

Uniprot No.	P54819
Target Names	AK2
Alternative Names	Adenylate kinase 2 antibody; adenylate kinase 2, mitochondrial antibody; Adenylate kinase isoenzyme 2 antibody; ADK2 antibody; AK 2 antibody; ak2 antibody; ATP AMP transphosphorylase antibody; ATP-AMP transphosphorylase 2 antibody; EC 2.7.4.3 antibody; KAD2_HUMAN antibody; mitochondrial antibody
Raised in	Rabbit
Species Reactivity	Human,Mouse,Rat,Zebrafish
Immunogen	Human AK2
Immunogen Species	Homo sapiens (Human)
Isotype	IgG
Purification Method	Antigen Affinity Purified
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications	ELISA,WB,IHC,IF
Protocols	ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time	Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
Gene References into Functions	Genetic variants of AK2 activates tenofovir for HIV therapy. PMID: 29641561 Reticular dysgenesis -patient derived induced pluripotent stem cells can recapitulate disease phenotype which can be rescued by AK2 overexpression. PMID: 29462620 In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 strongly influences osteoblast differentiation from bone marrow stromal cells. PMID: 27422603 AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages. PMID: 26270350 results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth. PMID: 24548998 AK2 is indispensable for neutrophil differentiation, indicating a possible causative link between AK2 deficiency and neutropenia in reticular dysgenesis. PMID: 24587121 These results suggest that, acting in concert with FADD and caspase-10, AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis. PMID: 17952061 The alpha-borano or alpha-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP kinases 2 PMID: 18404568 Biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis and sensorineural deafness, were identified. PMID: 19043416 The gene encoding the mitochondrial energy metabolism enzyme adenylate kinase 2 (AK2) is mutated in individuals with reticular dysgenesis. PMID: 19043417 Show More Hide All
Involvement in disease	Reticular dysgenesis (RDYS)
Subcellular Location	Mitochondrion intermembrane space
Protein Families	Adenylate kinase family, AK2 subfamily
Tissue Specificity	Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood,
Database Links	HGNC: 362 OMIM: 103020 KEGG: hsa:204 STRING: 9606.ENSP00000346921 UniGene: Hs.470907

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Code	CSB-PA001509GA01HU
Size	US$685
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