AKAP4 Antibody

Datasheet

Code	CSB-PA311022
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA311022(AKAP4 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA311022(AKAP4 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q5JQC9

Target Names

AKAP4

Alternative Names

A kinase (PRKA) anchor protein 4 antibody; A kinase anchor protein 4 antibody; A kinase anchor protein 82 kDa antibody; A-kinase anchor protein 4 antibody; A-kinase anchor protein 82 kDa antibody; AKAP 4 antibody; AKAP 82 antibody; AKAP-4 antibody; AKAP4 antibody; AKAP4_HUMAN antibody; AKAP82 antibody; FSC 1 antibody; FSC1 antibody; hAKAP 82 antibody; hAKAP82 antibody; HI antibody; Major sperm fibrous sheath protein antibody; p82 antibody; PRKA 4 antibody; PRKA4 antibody; Protein kinase A anchoring protein 4 antibody; Protein kinase A-anchoring protein 4 antibody; Testis specific gene HI antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Fusion protein of Human AKAP4

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Major structural component of sperm fibrous sheath. Plays a role in sperm motility.

Gene References into Functions

High AKAP4 expression is associated with reduced sperm motility. PMID: 29581387
A significant association was found between AKAP4 gene expression and metastasis (P-value: 0.045), expression of the CTAG1B (NY-ESO-1) gene was not observed in our cases. PMID: 29480665
the physiological role of the negative crosstalk between the cAMP/PKA/AKAP4 and the PKC/ERK1/2 pathways is to regulate capacitation and acrosome reaction. PMID: 27901058
AKAP4 role in the proliferation and metastasis of thyroid cancer.AKAP4 is highly expressed in thyroid cancer. PMID: 27983916
AKAP4 appears to be a novel Colorectal cancer-associated antigen with a potential for developing as a new clinical therapeutic target PMID: 26590805
AKAP4 is a highly accurate biomarker for the detection of early stage lung cancer. PMID: 26160834
SP17/AKAP4/PTTG1 are expressed in both human NSCLC cell lines and primary tumors and can elicit an immunogenic response in lung cancer patients. PMID: 25739119
The putative role of AKAP4 in early tumorigenesis is implicated as a biomarker and immunotherapeutic target for cervical cancer. PMID: 23478221
Ablation of AKAP4 protein caused significant inhibition in cellular proliferation, colony-forming ability, migration and invasion ability of tumor cells. PMID: 23764900
data suggests that AKAP4 may be used as serum based diagnostic test for an early detection and diagnosis of breast cancer and may be a potential target for immunotherapeutic use PMID: 23451156
We demonstrate the aberrant expression of AKAP-4 in prostate cancer, which will potentially be developed as a biomarker in prostate cancer. PMID: 21520158
AKAP4 is a novel target for protein S-nitrosylation in spermatozoa. PMID: 17683036
Role of AKAP4 in sperm motility is unclear, vut absent or weak AKAP4-labelling is associated with absent or weak sperm. motility. PMID: 17712481

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Subcellular Location

Cell projection, cilium, flagellum. Note=Localizes to the principle piece of the sperm flagellum.

Protein Families

AKAP110 family

Tissue Specificity

Testis specific; only expressed in round spermatids.

Database Links

HGNC: 374

OMIM: 300185

KEGG: hsa:8852

STRING: 9606.ENSP00000351327

UniGene: Hs.97633

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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