AMPD2 Antibody

Code CSB-PA001681GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
Adenosine monophosphate deaminase 2 (isoform L) antibody; Adenosine monophosphate deaminase 2 antibody; adenosine monophosphate deaminase 2 isoform L antibody; AMP deaminase 2 antibody; AMP deaminase isoform L antibody; AMPD 2 antibody; AMPD antibody; AMPD2 antibody; AMPD2_HUMAN antibody; RP5-1160K1.5 antibody; SPG63 antibody
Raised in
Species Reactivity
Human AMPD2
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.
Gene References into Functions
  1. Here we report the clinical and genetic analysis of an individual with PCH9 secondary to a novel missense variant with strong evidence of pathogenicity, located outside the catalytic domain of AMPD2 PMID: 28168832
  2. tofacitinib increases the cellular levels of adenosine, which is known to have anti-inflammatory activity, through the downregulation of AMPD2. This would be a novel functional aspect of tofacitinib. PMID: 25496463
  3. In human HepG2 cells, AMPD2 activation counterregulates AMPK and increases intracellular glucose production, in association with up-regulation of PEPCK and G6Pc. PMID: 24755741
  4. Study concluded that AMPD2 as necessary for guanine nucleotide biosynthesis and protein translation and provide evidence that AMP deaminase activity is critical during neurogenesis. Patients with mutations in AMPD2 have characteristic brain imaging features of pontocerebellar hypoplasia due to loss of brainstem and cerebellar parenchyma. PMID: 23911318
  5. N-terminal extensions of the AMPD2 polypeptide influence ATP regulation of isoform L. PMID: 12745092

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Involvement in disease
Pontocerebellar hypoplasia 9 (PCH9); Spastic paraplegia 63, autosomal recessive (SPG63)
Protein Families
Metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family
Tissue Specificity
Highly expressed in cerebellum.
Database Links

HGNC: 469

OMIM: 102771

KEGG: hsa:271

STRING: 9606.ENSP00000256578

UniGene: Hs.82927

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