AMPD2 Antibody

Datasheet

Code	CSB-PA001681LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001681LA01HU at dilution of 1:100 Immunofluorescent analysis of MCF-7 cells using CSB-PA001681LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Western Blot Positive WB detected in: U87 whole cell lysate All lanes: AMPD2 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 101, 93, 89 kDa Observed band size: 101 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) AMPD2 Polyclonal antibody

Uniprot No.

Q01433

Target Names

AMPD2

Alternative Names

Adenosine monophosphate deaminase 2 (isoform L) antibody; Adenosine monophosphate deaminase 2 antibody; adenosine monophosphate deaminase 2 isoform L antibody; AMP deaminase 2 antibody; AMP deaminase isoform L antibody; AMPD 2 antibody; AMPD antibody; AMPD2 antibody; AMPD2_HUMAN antibody; RP5-1160K1.5 antibody; SPG63 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human AMP deaminase 2 protein (1-129AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The AMPD2 Antibody (Product code: CSB-PA001681LA01HU) is Non-conjugated. For AMPD2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA001681LB01HU	AMPD2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA001681LC01HU	AMPD2 Antibody, FITC conjugated
Biotin	CSB-PA001681LD01HU	AMPD2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.

Gene References into Functions

Here we report the clinical and genetic analysis of an individual with PCH9 secondary to a novel missense variant with strong evidence of pathogenicity, located outside the catalytic domain of AMPD2 PMID: 28168832
tofacitinib increases the cellular levels of adenosine, which is known to have anti-inflammatory activity, through the downregulation of AMPD2. This would be a novel functional aspect of tofacitinib. PMID: 25496463
In human HepG2 cells, AMPD2 activation counterregulates AMPK and increases intracellular glucose production, in association with up-regulation of PEPCK and G6Pc. PMID: 24755741
Study concluded that AMPD2 as necessary for guanine nucleotide biosynthesis and protein translation and provide evidence that AMP deaminase activity is critical during neurogenesis. Patients with mutations in AMPD2 have characteristic brain imaging features of pontocerebellar hypoplasia due to loss of brainstem and cerebellar parenchyma. PMID: 23911318
N-terminal extensions of the AMPD2 polypeptide influence ATP regulation of isoform L. PMID: 12745092

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Involvement in disease

Pontocerebellar hypoplasia 9 (PCH9); Spastic paraplegia 63, autosomal recessive (SPG63)

Protein Families

Metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family

Tissue Specificity

Highly expressed in cerebellum.

Database Links

HGNC: 469

OMIM: 102771

KEGG: hsa:271

STRING: 9606.ENSP00000256578

UniGene: Hs.82927

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Service

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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