ANKRD2 Antibody, HRP conjugated

Code CSB-PA875635LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ANKRD2 Polyclonal antibody
Uniprot No.
Target Names
ANKRD2
Alternative Names
ANKRD2 antibody; ARPPAnkyrin repeat domain-containing protein 2 antibody; Skeletal muscle ankyrin repeat protein antibody; hArpp antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ankyrin repeat domain-containing protein 2 protein (1-210AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.
Gene References into Functions
  1. The results set the stage for investigation of the specific functions and interactions of the Ankrd2 isoforms in healthy and diseased human striated muscles. PMID: 27393496
  2. The Ankrd2 was found to be expressed in both the cytoplasm and nucleus, independently from maturation status of cardiomyocytes. PMID: 25585647
  3. Report structure activity relationships for ANKRD2. PMID: 25125175
  4. Ankrd2 as a potent repressor of inflammatory responses through direct interaction with the NF-kappaB repressor subunit p50. PMID: 24434510
  5. The orthologs of ANKRD2 in mouse and rat, which are also titin binding proteins, are stretch-response genes associated with slow muscle function and these proteins are part of a separate mechanotransduction system to the one that regulates muscle mass. PMID: 15677738
  6. Although analyzed in a limited number of patients, there is a considerable body of evidence that MARP proteins could be suitable candidates for prognostic and diagnostic biomarkers. PMID: 22185618
  7. Ankrd2 is a potent regulator in muscle cells affecting a multitude of pathways and processes PMID: 22016770
  8. Ankrd2 is a novel Akt2 specific substrate and regulates myogenic differentiation PMID: 21737686
  9. These findings suggest that type-specific expression patterns of ARPP and CARP are altered in skeletal muscles of amyotrophic lateral sclerosis. PMID: 12679596
  10. Ankrd2 may be involved in sensing stress signals and linking these to muscle gene regulation PMID: 15136035
  11. Arpp is a novel skeletal muscle-specific marker, which is useful for differential diagnosis of rhabdomyosarcoma PMID: 16021567
  12. ARPP was localized in mitochondria and nuclei in both the normal distal renal tubule and oncocytoma but not in chromophobe renal cell carcinomas. PMID: 17206105

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Subcellular Location
Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.
Tissue Specificity
Mostly expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a lower extent (at protein level).
Database Links

HGNC: 495

OMIM: 610734

KEGG: hsa:26287

STRING: 9606.ENSP00000306163

UniGene: Hs.73708

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