ANO6 Antibody, HRP conjugated

Code CSB-PA679761LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ANO6 Polyclonal antibody
Uniprot No.
Target Names
ANO6
Alternative Names
2900059G15Rik antibody; AA407480 antibody; Ano6 antibody; ANO6_HUMAN antibody; Anoctamin 6 antibody; Anoctamin-6 antibody; AW554778 antibody; BDPLT7 antibody; F730003B03Rik antibody; MGC104751 antibody; SCTS antibody; TMEM16F antibody; Transmembrane protein 16F antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Anoctamin-6 protein (12-100AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.; Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia.
Gene References into Functions
  1. ICl,Swell, and cell volume are regulated by Ano6. The findings suggest a novel clinically-relevant approach for altering cell volume, and thereby outflow resistance, by targeting Ano6. PMID: 28125837
  2. TMEM16F modifies viability of Human Embryonic Kidney cells via its function as a phospholipid scramblase and activation of AKT signaling pathways. PMID: 27287741
  3. Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms PMID: 26108457
  4. deficiency in Ano6 resulted in reduced viability with increased bleeding time PMID: 26481309
  5. ANO6 is highly expressed in apoptotic cyst epithelial cells of human polycystic kidneys. PMID: 26448322
  6. Homology modeling shows that the scramblase domain forms an unusual hydrophilic cleft that faces the lipid bilayer and may function to facilitate translocation of phospholipid between membrane leaflets. PMID: 26057829
  7. Ano6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. PMID: 25651887
  8. using human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone matrix PMID: 25589784
  9. Anoo6 induces a chloride ion conductance along with a smaller nonselective cation conductance that is activated either calcium ion dependently (ionomycin) or calcium independently(fas receptor), but not during mitochondrial apoptosis. PMID: 23618909
  10. a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population PMID: 23308121
  11. TMEM16F is an essential component of a divalent calcium ion-activated Cl- channel with a divalent calcium ion sensitivity that is distinct from that of TMEM16A/B and not related to volume-sensitive outwardly rectifying Cl- channel (VSOR) activity. PMID: 23426967
  12. It scrambles phospholipids in cell membrane and its mutation leads to Scott syndrome. (review) PMID: 22256604
  13. Study identified 2 novel mutations in the TMEM16F gene in 2 patients with Scott syndrome. PMID: 21511967
  14. Wild-type TMEM16F was localized on the plasma membrane and conferred Ca(2+)-dependent scrambling of phospholipids PMID: 21107324

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Involvement in disease
Scott syndrome (SCTS)
Subcellular Location
Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization according to PubMed:22075693.
Protein Families
Anoctamin family
Tissue Specificity
Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer.
Database Links

HGNC: 25240

OMIM: 262890

KEGG: hsa:196527

STRING: 9606.ENSP00000409126

UniGene: Hs.505339

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