ANO7 Antibody

Code CSB-PA776558
Size US$297
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  • Western blot analysis of extracts from LOVO cells, using TM16G antiobdy.
  • Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using TM16G antibody.
  • Immunofluorescence analysis of HepG2 cells, using TM16G antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ANO7 Polyclonal antibody
Uniprot No.
Target Names
ANO7
Alternative Names
Ano7 antibody; ANO7_HUMAN antibody; Anoctamin 7 antibody; Anoctamin-7 antibody; D TMPP antibody; D-TMPP antibody; Dresden transmembrane protein of the prostate antibody; DTMPP antibody; IPCA 5 antibody; IPCA-5 antibody; IPCA5 antibody; New gene expressed in prostate antibody; NGEP antibody; PCANAP5 antibody; PCANAP5L antibody; Prostate cancer associated protein 5 antibody; Prostate cancer-associated protein 5 antibody; TMEM16G antibody; Transmembrane protein 16G antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from C-terminal of Human TM16G.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.
Gene References into Functions
  1. high level of NGEP expression could be associated with good prognosis in prostate cancer PMID: 25808443
  2. NGEP protein is widely expressed in low-grade to high-grade prostate adenocarcinomas as well as benign prostate tissues, and the intensity of expression is inversely proportional to the level of malignancy. PMID: 23955683
  3. expressed only in prostate and prostate camcer is a promising target for the antibody-based therapies of prostate cancer PMID: 14981236
  4. Complete coding sequence of TMEM16G cDNA was determined by assembling 25 exons of TMEM16G gene PMID: 15375614
  5. description of the novel prostate-restricted molecule D-TMPP widely expressed in prostate cancer tissues PMID: 15761874
  6. NGEP is a glycoprotein with predicted glycosylation sites at N809 and N824. When these residues were converted to glutamine, glycosylation was abolished, confirming that the residues are extracellular PMID: 18676855
  7. NGEP is a potential target for T cell-mediated immunotherapy of prostate cancer. PMID: 19495750

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Subcellular Location
[Isoform 1]: Cell membrane; Multi-pass membrane protein. Cell junction. Endoplasmic reticulum.; [Isoform 2]: Cytoplasm, cytosol.
Protein Families
Anoctamin family
Tissue Specificity
Specifically expressed in epithelial cells of the prostate (at protein level).
Database Links

HGNC: 31677

OMIM: 605096

KEGG: hsa:50636

STRING: 9606.ENSP00000274979

UniGene: Hs.163909

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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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