AP1G1 Antibody

Datasheet

Code	CSB-PA248283
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA248283(AP1G1 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Target Background

Product Details

Uniprot No.

O43747

Target Names

AP1G1

Alternative Names

Adapter-related protein complex 1 subunit gamma-1 antibody; Adaptor protein complex AP 1 gamma 1 subunit antibody; Adaptor protein complex AP 1 subunit gamma 1 antibody; Adaptor protein complex AP-1 subunit gamma-1 antibody; Adaptor related protein complex 1 gamma 1 subunit antibody; ADTG antibody; AP 1 complex subunit gamma 1 antibody; AP-1 complex subunit gamma-1 antibody; AP1G1 antibody; AP1G1_HUMAN antibody; CLAPG1 antibody; Clathrin assembly protein complex 1 gamma 1 large chain antibody; Clathrin assembly protein complex 1 gamma large chain antibody; Clathrin assembly protein complex 1 gamma-1 large chain antibody; Clathrin associated/assembly/adaptor protein large gamma 1 antibody; Gamma1 adaptin antibody; Gamma1-adaptin antibody; Golgi adaptor HA1/AP1 adaptin gamma subunit antibody; Golgi adaptor HA1/AP1 adaptin subunit gamma 1 antibody; Golgi adaptor HA1/AP1 adaptin subunit gamma-1 antibody; MGC18255 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human AP1G1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes.

Gene References into Functions

Data indicate a functional link between adaptor protein complex 1 (AP-1) and the WD repeat protein 11 (WDR11) complex. PMID: 29426865
High ASCT2 expression is associated with drug resistance head and neck squamous cell carcinoma. PMID: 28823958
Depletion of the gamma2 or mu1A (AP1M1) subunits of AP-1, but not of gamma1 (AP1G1), precludes Nef-mediated lysosomal degradation of CD4. PMID: 27909244
Interaction between Rab4b and AP1gamma allows the budding of clathrin-coated vesicles for subsequent traffic to recycling endosomes. PMID: 24006255
Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain.The interaction may play a role in membrane trafficking between the trans-Golgi network and endosomes. PMID: 11872161
crystal structure of the human gamma 1-adaptin ear domain consists solely of an immunoglobulin-like fold, unlike the alpha-adaptin ear domain PMID: 12042876
Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation PMID: 16867982

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Subcellular Location

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle.

Protein Families

Adaptor complexes large subunit family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 555

OMIM: 603533

KEGG: hsa:164

STRING: 9606.ENSP00000377148

UniGene: Hs.461253

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Phage Display Service

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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