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AP1G1 Antibody

Datasheet
Code CSB-PA248283
Size US$166
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Image
  • Immunohistochemistry(IHC) - AP1G1 Antibody
    The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA248283(AP1G1 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
O43747
Target Names
AP1G1
Alternative Names
Adapter-related protein complex 1 subunit gamma-1 antibody; Adaptor protein complex AP 1 gamma 1 subunit antibody; Adaptor protein complex AP 1 subunit gamma 1 antibody; Adaptor protein complex AP-1 subunit gamma-1 antibody; Adaptor related protein complex 1 gamma 1 subunit antibody; ADTG antibody; AP 1 complex subunit gamma 1 antibody; AP-1 complex subunit gamma-1 antibody; AP1G1 antibody; AP1G1_HUMAN antibody; CLAPG1 antibody; Clathrin assembly protein complex 1 gamma 1 large chain antibody; Clathrin assembly protein complex 1 gamma large chain antibody; Clathrin assembly protein complex 1 gamma-1 large chain antibody; Clathrin associated/assembly/adaptor protein large gamma 1 antibody; Gamma1 adaptin antibody; Gamma1-adaptin antibody; Golgi adaptor HA1/AP1 adaptin gamma subunit antibody; Golgi adaptor HA1/AP1 adaptin subunit gamma 1 antibody; Golgi adaptor HA1/AP1 adaptin subunit gamma-1 antibody; MGC18255 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide of Human AP1G1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:5000
IHC 1:25-1:100
Protocols
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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AP1G1 Antibodies

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Target Background

Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes.
Gene References into Functions
  1. Data indicate a functional link between adaptor protein complex 1 (AP-1) and the WD repeat protein 11 (WDR11) complex. PMID: 29426865
  2. High ASCT2 expression is associated with drug resistance head and neck squamous cell carcinoma. PMID: 28823958
  3. Depletion of the gamma2 or mu1A (AP1M1) subunits of AP-1, but not of gamma1 (AP1G1), precludes Nef-mediated lysosomal degradation of CD4. PMID: 27909244
  4. Interaction between Rab4b and AP1gamma allows the budding of clathrin-coated vesicles for subsequent traffic to recycling endosomes. PMID: 24006255
  5. Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain.The interaction may play a role in membrane trafficking between the trans-Golgi network and endosomes. PMID: 11872161
  6. crystal structure of the human gamma 1-adaptin ear domain consists solely of an immunoglobulin-like fold, unlike the alpha-adaptin ear domain PMID: 12042876
  7. Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation PMID: 16867982

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Subcellular Location
Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle.
Protein Families
Adaptor complexes large subunit family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 555

OMIM: 603533

KEGG: hsa:164

STRING: 9606.ENSP00000377148

UniGene: Hs.461253

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