APEH Antibody

Code CSB-PA194613
Size US$299 How to order?
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA194613(APEH Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA194613(APEH Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details

Uniprot No. P13798
Target Names APEH
Alternative Names AARE antibody; ACPH antibody; ACPH_HUMAN antibody; Acyl peptide hydrolase antibody; Acyl-peptide hydrolase antibody; Acylamino acid releasing enzyme antibody; Acylamino-acid-releasing enzyme antibody; Acylaminoacyl peptidase antibody; Acylaminoacyl-peptidase antibody; APEH antibody; APH antibody; N acylaminoacyl peptide hydrolase antibody; OPH antibody; Oxidized protein hydrolase antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthetic peptide of Human APEH
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.
Gene References into Functions
  1. Although APEH is primarily localized in the cytoplasm, a sub-fraction of this enzyme is sequestered at sites of nuclear damage following UVA irradiation or following oxidative stress. APEH interacts with the amino-terminal domain of XRCC1, and APEH facilitates both single-strand break repair and cell survival following exposure to H2O2. Thus, APEH as a novel proteolytic component of the DNA damage response. PMID: 28866241
  2. APEH polymorphism has significant influence on valproic acid pharmacokinetics in Chinese population PMID: 27406852
  3. Studies indicate that the cylindromatosis/turban tumor syndrome gene (CYLD) ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4). PMID: 21931648
Subcellular Location Cytoplasm.
Protein Families Peptidase S9C family
Database Links

HGNC: 586

OMIM: 102645

KEGG: hsa:327

STRING: 9606.ENSP00000296456

UniGene: Hs.517969

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Address
7505 Fannin St. Ste 610-312, Houston, TX 77054, USA
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