ARFGAP1 Antibody

1. ARFGAP1 is found associated with lipid droplets at steady state in some but not all hepatocytes. PMID: 25397679
2. ARFGAP1 is a host factor for Hepatitis C Virus RNA replication, and is hijacked by HCV NS5A to remove COPI cargo Sac1 from the site of HCV replication to maintain high levels of PI4P. PMID: 24623438
3. ArfGAP1 is identified as the first GTPase activating protein (GAP) for leucine-rich repeat kinase 2 (LRRK2). PMID: 22423108
4. role of ARFGAP1 in AP-2-regulated endocytosis has mechanistic parallels with its roles in COPI transport, as both its GAP activity and coat function contribute to promoting AP-2 transport PMID: 21499258
5. The small GTPases of the Ras superfamily mediate numerous biological processes through their ability to cycle between an inactive GDP-bound and an active GTP-bound form. PMID: 15246431
6. ArfGAP1 interacts with the Golgi through multiple hydrophobic motifs and that alternative modes of interaction may exist in tissue-specific ArfGAP1 isoforms. PMID: 16316994
7. SMAP2 functions in the retrograde, early endosome-to-trans golig network pathway in a clathrin- and AP-1-dependent manner. PMID: 16571680
8. coatomer is an allosteric regulator of Arf GAP1 PMID: 18541532
9. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking PMID: 19015319
10. catalytic amounts of Arf1GAP1 significantly reduce the yield of purified COPI vesicles PMID: 19055691
11. ArfGAP1, ArfGAP2, and ArfGAP3 have overlapping roles in regulating COPI function in Golgi-to-ER retrograde transport. PMID: 19299515

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HGNC: 15852

OMIM: 608377

KEGG: hsa:55738

STRING: 9606.ENSP00000314615

UniGene: Hs.25584