ARFGEF2 Antibody

1. Both phospholipase D activity and vesicular trafficking were required for effects of BIG1 and BIG2 on beta-catenin activation. Levels of PKA-phosphorylated beta-catenin S675 and beta-catenin association with PKA, BIG1, and BIG2 were also diminished after BIG1/BIG2 depletion. PMID: 27162341
2. Description of a novel ARFGEF2 mutation in five related patients presenting with West syndrome, microcephaly, periventricular heterotopia and thin corpus callosum. PMID: 23812912
3. The clinical phenotype associated with mutations in ARFGEF2 is relatively homogeneous in the families report. PMID: 23755938
4. Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex. PMID: 23918382
5. an early acting GEF (GBF1) activates ARFs that mediate recruitment of late acting GEFs (BIG1/2) to coordinate coating events within the pre-Golgi/Golgi/TGN continuum. PMID: 23386609
6. Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin beta1 cycling and actin remodeling. PMID: 22908276
7. Up-regulation of ARFGEF2 is associated with the Huntington's disease. PMID: 21309479
8. BIG1 and BIG2 have roles in endomembrane organization PMID: 20360857
9. involvement in molecular mechanisms of vesicular transport PMID: 11665623
10. identification of protein kinase A-anchoring domains PMID: 12571360
11. BIG2 and Exo70 interact in trans-Golgi network and centrosomes, as well as in exocyst structures or complexes that move along microtubules to the plasma membrane. PMID: 15705715
12. ARFGEF2 mRNA was widely expressed in all cortical layers, especially in the neural precursors of the ventricular and subventricular zones during development, with persistent but diminished expression in adulthood. PMID: 16320251
13. Regulates the constitutive release of tumor necrosis factor receptor type 1 exosome-like vesicles from vascular endothelial cells. PMID: 17276987
14. Phosphorylation of BIG1 and BIG2 via PKA and protein phosphatase 1gamma effects vesicular trafficking via alterations in ARF activation. PMID: 17360629
15. COPII is the only coat required for sorting and export from the endoplasmic reticulum exit sites, whereas GBF1 but not BIGs, is required for COPI recruitment, Golgi subcompartmentalization, and cargo progression to the cell surface. PMID: 18003980
16. These observations indicate that BIG2 and BIG1 play redundant roles in trafficking between the trans-Golgi network and endosomes that involves the AP-1 complex. PMID: 18417613
17. both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C PMID: 18625701
18. Results describe a child with a severe choreadystonic movement disorder, bilateral periventricular nodular heterotopia (BPNH), and secondary microcephaly based on compound heterozygosity for two new ARFGEF2 mutations. PMID: 19384555

Show More

Hide All

HGNC: 15853

OMIM: 605371

KEGG: hsa:10564

STRING: 9606.ENSP00000360985

UniGene: Hs.62578