ARL2BP Antibody

Code CSB-PA002081GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
ARL2BP
Alternative Names
ADP ribosylation factor like 2 binding protein antibody; ADP-ribosylation factor-like protein 2-binding protein antibody; AR2BP_HUMAN antibody; Arf like 2 binding protein BART1 antibody; ARF-like 2-binding protein antibody; ARL2 binding protein antibody; Arl2bp antibody; ARL2BP protein antibody; BART antibody; BART1 antibody; Binder of ARF2 protein 1 antibody; Binder of Arl Two antibody; Binder of Arl2 antibody; Retinitis pigmentosa 66 (autosomal recessive) antibody; RP66 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human ARL2BP
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
Gene References into Functions
  1. This study identified two homozygous variants in ARL2BP as a rare cause of autosomal recessive retinitis pigmentosa. Further studies are required to define the underlying disease mechanism causing retinal degeneration as a result of mutations in ARL2BP and any phenotype-genotype correlation associated with residual levels of the wild-type transcript. PMID: 30210231
  2. Subsequent analysis of 844 index cases did not reveal further pathogenic chances in ARL2BP indicating that mutations in ARL2B are a rare cause of arRCD (about 0.1%) in a large cohort of French patients. PMID: 27790702
  3. Alteration of EBV encoded miR-BART1 expression results in an increase in migration and invasion of nasopharyngeal carcinoma in vitro and causes metastasis in vivo. EBV-miR-BART1 directly targets the cellular tumour suppressor PTEN. PMID: 26135619
  4. EBV also downregulates two immediate early genes by miR-BART20-5p. PMID: 24899173
  5. Mutations in ARL2BP cause autosomal-recessive retinitis pigmentosa. PMID: 23849777
  6. EBV-miR-BART1 could influence the expression of metabolism-associated genes and might be involved in cancer metabolism in nasopharyngeal carcinoma PMID: 23685147
  7. Our results imply that BART regulates actin-cytoskeleton rearrangements at membrane ruffles through modulation of the activity of Rac1, which, in turn, inhibits pancreatic cancer cell invasion. PMID: 22745590
  8. These results imply that BART contributes to regulating PKCalpha activity through binding to ANX7, thereby affecting the invasiveness of pancreatic cancer cells. PMID: 22532868
  9. We identify a subset of BART miRNAs that are restricted to Latency III in normal infection but are up regulated in tumors that express Latency I and II. PMID: 21901094
  10. Our results imply that BART increases active RhoA by inhibiting ARL2 function, which in turn inhibits invasiveness of cancer cells. PMID: 21833473
  11. Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector. PMID: 19368893

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Involvement in disease
Retinitis pigmentosa with or without situs inversus (RPSI)
Subcellular Location
Cytoplasm. Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body.
Protein Families
ARL2BP family
Tissue Specificity
Expressed in retina pigment epithelial cells (at protein level). Widely expressed.
Database Links

HGNC: 17146

OMIM: 615407

KEGG: hsa:23568

STRING: 9606.ENSP00000219204

UniGene: Hs.632873

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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