ARL2BP Antibody

Datasheet
Code CSB-PA002081GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. Q9Y2Y0
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Human ARL2BP
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,IHC
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity Purified
Isotype IgG
Alias ADP-ribosylation factor-like 2 binding protein;ARL2BP;BART;BART1 ;
Immunogen Species Homo sapiens (Human)
Target Names ARL2BP
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. This protein binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity.
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Function Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
Involvement in disease Retinitis pigmentosa with or without situs inversus (RPSI)
Subcellular Location Cytoplasm, Mitochondrion intermembrane space, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus, Cytoplasm, cytoskeleton, spindle, Cytoplasm, cytoskeleton, cilium basal body
Protein Families ARL2BP family
Tissue Specificity Expressed in retina pigment epithelial cells (at protein level). Widely expressed.
Database Links

HGNC: 17146

OMIM: 615407

KEGG: hsa:23568

STRING: 9606.ENSP00000219204

UniGene: Hs.632873

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