ATP4B Antibody, FITC conjugated

Datasheet

Code	CSB-PA002343EC01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ATP4B Polyclonal antibody

Uniprot No.

P51164

Target Names

ATP4B

Alternative Names

Gastric H(+)/K(+) ATPase subunit beta antibody; ATP4B antibody; ATP4B_HUMAN antibody; ATP6B antibody; ATPase H+/K+ exchanging beta polypeptide antibody; ATPase H+/K+ transporting beta polypeptide antibody; Gastric H K ATPase catalytic subunit antibody; Gastric H(+)/K(+) ATPase subunit beta antibody; Gastric H+/K+ ATPase beta subunit antibody; Gastric hydrogen potassium ATPase antibody; Gastric hydrogen potassium ATPase beta antibody; Hydrogen/potassium exchanging ATPase 4B antibody; OTTHUMP00000178856 antibody; Parietal cell antigen antibody; Potassium transporting ATPase beta chain antibody; Potassium transporting ATPase subunit beta antibody; Potassium-transporting ATPase subunit beta antibody; Proton pump antibody; Proton pump beta chain antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Potassium-transporting ATPase subunit beta protein (58-291AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle.

Gene References into Functions

these findings demonstrated that a decrease in pHi, caused by H+/K+-ATPase inhibition induced by BMT-1, triggered the dysfunction of the mitochondria resulting in the apoptosis of MM cells PMID: 24700195
Downregulation of ATP4B gene is associated with gastric cancer. PMID: 23317218
BCL-2 inhibits formation of reactive oxygen species. PMID: 11865975
Content of the beta1 subunit of sodium potassium pump in resistance trained control subjects was 33% higher in trained compared to untrained leg, and 47% higher in trained compared to untrained leg in diabetics. PMID: 14685860
Thus prolonged exhaustive exercise impaired each of the maximal in vitro Na+-K+-ATPase activity, Ca2+ release, and Ca2+ uptake rates. PMID: 15155714
Use of fold recognition methods enables the prediction that a C-terminal domain of the beta subunits of Na,K-ATPase and H,K-ATPase has an immunoglobulin-like fold, which resembles cell adhesion molecules. PMID: 19694409

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Subcellular Location

Apical cell membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein.

Protein Families

X(+)/potassium ATPases subunit beta family

Database Links

HGNC: 820

OMIM: 137217

KEGG: hsa:496

STRING: 9606.ENSP00000334216

UniGene: Hs.434202

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Oxidative Phosphorylation

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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