AVPR2 Antibody

Code CSB-PA987235
Size US$166
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  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA987235(AVPR2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA987235(AVPR2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
Alternative Names
ADHR antibody; Antidiuretic hormone receptor antibody; Arginine vasopressin receptor 2 antibody; AVP R2 antibody; AVPR 2 antibody; AVPR V2 antibody; AVPR2 antibody; DI1 antibody; DIR 3 antibody; DIR antibody; DIR3 antibody; MGC126533 antibody; MGC138386 antibody; NDI antibody; Nephrogenic diabetes insipidus antibody; Renal type arginine vasopressin receptor antibody; Renal-type arginine vasopressin receptor antibody; V2 receptor antibody; V2R antibody; V2R_HUMAN antibody; Vasopressin V2 antibody; Vasopressin V2 receptor antibody
Raised in
Species Reactivity
Synthetic peptide of Human AVPR2
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen affinity purification
It differs from different batches. Please contact us to confirm it.
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Tested Applications
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:5000
IHC 1:25-1:100
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.
Gene References into Functions
  1. Being a rapid diagnostic tool for congenital nephrogenic diabetes insipidus , direct sequencing of AVPR2 should be encouraged in newborns with familial predisposition to congenital nephrogenic diabetes insipidus. PMID: 29594432
  2. A novel 22.1-kb deletion in AVPR2 was identified, leading to X-linked nephrogenic diabetes insipidus in a Chinese pedigree. PMID: 29394883
  3. Here we provide an updated overview of the genetic defects causing NDI, the most recent strategies under investigation for rescuing the activity of mutated AVPR2 or AQP2, or for bypassing defective AVPR2 signaling and restoring AQP2 plasma membrane expression. PMID: 29125546
  4. Data found Mutations of Vasopressin Receptor 2 Including Novel L312S Have Differential Effects on Trafficking PMID: 27355191
  5. An overview of AVPR2 mutations in genetic forms of nephrogenic diabetes insipidus (review) PMID: 27156763
  6. this case report describes a case of congenital nephrogenic diabetes insipidus with an AVPR2 gene I324M missense mutation; this is the first report of this mutation in patients with congenital nephrogenic diabetes insipidus PMID: 27565746
  7. the canceling of the desensitization effect of OPC51803 by the pharmacochaperone effect after long-term treatment may produce sustainable signaling, and thus pharmacochaperone agonists such as OPC51803 may serve as promising therapeutics for NDI caused by misfolded V2R mutants. PMID: 27601473
  8. AVPR2 missense mutation is associated with nephrogenic diabetes insipidus. PMID: 26974133
  9. Data suggest that the congenital congenital nephrogenic diabetes insipidus (NDI) in the patient, his mother and grandmother was probably due to mutation of the arginine vasopressin receptor 2 (AVPR2) gene. PMID: 27577218
  10. a splice site mutation in AVPR2 leads to partial X-linked NDI in two brothers. PMID: 26795631
  11. A heterozygous deletion in exon 1 of the AVPR2 gene is associated with nephrogenic diabetes insipidus. PMID: 26244674
  12. In this study, we identified and characterized a new gain-of function mutation of the V2R, which leads to nephrogenic syndrome of inappropriate diuresis. PMID: 26131744
  13. We present a novel mutation in codon 137 within AVPR2 with substitution of glycine for arginine in male dizygotic twins. PMID: 27117808
  14. Rescue of the N321K-V2R function by Val(4)-desmopressin action in nephrogenic diabetes insipidus. PMID: 24628417
  15. X-linked nephrogenic diabetes insipidus and severity of illness in this family is caused by a novel deletion in the AVPR2 gene PMID: 24026507
  16. AVP acting at V2R does not appear to regulate water losses from body fluids other than renal excretion during exercise. PMID: 24944242
  17. This review summarizes some of the unexpected roles of V2R signaling and suggests that vasopressin signaling itself may contribute crucially to loss of polarity and enhanced proliferation in cystic kidney epithelium. PMID: 24556353
  18. 52 disease-causing mutations of AVPR2 were identified. missense mutations were most common (54%), followed by deletion mutations. 64 women who had monoallelic disease-causing AVPR2 mutations, 16 had NDI symptoms, including 4 complete NDI subjects PMID: 23150186
  19. Three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V) may be related to nephrogenic syndrome of inappropriate antidiuresis and to nephrogenic diabetes insipidus. PMID: 23762448
  20. vasopressin receptor type 2 signaling is controlled by retromer and arrestin in a noncanonical regulatory pathway PMID: 23935101
  21. The V88M mutation is associated with phenotypical diversity, which may be explained by the fact that both the expression level and the hormone-binding affinity are affected by the mutation. PMID: 19816050
  22. No pathological variants affecting R137 were detected among the 5,142 AVPR2 alleles successfully genotyped. Even at the population extremes of serum sodium distribution, we estimate minor allele frequency PMID: 23362144
  23. crystal structure of beta-arrestin-1 (also called arrestin-2) in complex with a fully phosphorylated 29-amino-acid carboxy-terminal peptide derived from the human V2 vasopressin receptor (V2Rpp) PMID: 23604254
  24. Investigations into primary inherited nephrogenic diabetes insipidus (NDI) have contributed enormously to our understanding of the mechanisms of urinary concentration and identified the vasopressin receptor AVPR2, as well as the water channel aquaporin-2. PMID: 23364801
  25. Of the 15 patients with diabetes insipidus eight patients have AVPR2 mutations PMID: 22644838
  26. X-linked nephrogenic diabetes insipidus (NDI) and intellectual disability in two dizygotic twin brothers was caused by a novel contiguous deletion of 17,905 bp of the entire AVPR2 gene and intron 7 of the ARHGAP4 gene. PMID: 22965914
  27. The deletion mechanisms in the AVPR2 region do not follow the rules of non-allelic homologous recombination. Review. PMID: 22879391
  28. In this mini-review the retrospective analysis of 13 known AVPR2 mutations that have been previously shown in vitro to partially abolish AVPR2 function is described, along with a novel mutation diagnosed in a kindred with partial nephrogenic diabetes insipidus. [Review] PMID: 22386940
  29. Loss-of-function mutations in the vasopressin type 2 receptor gene is associated with nephrogenic diabetes insipidus. PMID: 21917732
  30. the minor haplotype constructs of AVPR2 SNPs were associated with larger body weight losses during the Ironman Triathlons. PMID: 22052024
  31. V2R antagonists can act as protean agonists, serving as pharmacological chaperones for inactivating V2R mutants and also as inverse agonists of wild-type receptors. PMID: 22144672
  32. It is suggested that disorder of V2R signaling in the endolymphatic sac for any reason could be involved in the pathogenesis of endolymphatic hydrops. PMID: 21574774
  33. A novel missense mutation c.506T > C (p.L169P) in AVPR2 in a patient with inherited nephrogenic diabetes insipidus. PMID: 22145481
  34. Overexpression of a V2R fragment corresponding to V2R-i3 as a fusion protein with thioredoxin A at the N-terminus and a hexahistidine tag between the two proteins. PMID: 21575724
  35. Our study shows for the first time that renal cancer may effectively synthesize and express the V2-R. PMID: 19217806
  36. no asp-lys-ile and asp-arg-tyr mutations significantly altered cAMP production and cell surface expression of V2R in these cells PMID: 20683494
  37. The 12E-V2R variant has increased binding affinity for AVP, resulting in increased signal transduction, and is associated with increased levels of VWF propeptide, VWF, and FVIII. PMID: 20403097
  38. study of two unrelated Thai boys with congenital nephrogenic diabetes insipidus; the novel AVPR2 mutation M311V retains partial activity and results in a milder form of nephrogenic diabetes insipidus PMID: 20389105
  39. The X-linked nephrogenic diabetes insipidus is caused by a novel mutation in the AVPR2 gene that is predicted to truncate the receptor protein. PMID: 19703807
  40. Amino acid substitution of AVPR2 induces the nephrogenic syndrome of inappropriate antidiuresis by reducing surface receptor levels and increasgin cycl AMP production. PMID: 20159941
  41. Absence of AVPR2 copy number variation in eunatremic and dysnatremic subjects in non-Hispanic Caucasian populations PMID: 19996159
  42. proteolytic cleavage of the V2 receptor requires a defined conformation and might play a role in signal termination at elevated hormone concentrations PMID: 10561596
  43. A novel type of contiguous gene deletion of AVPR2 has been identified in unrelated Japanese kindreds with nephrogenic diabetes insipidus. PMID: 11754100
  44. A new mutation associated with nephrogenic diabetes insipidus was isolated: a 6-AA deletion between G107 and C112. PMID: 11868598
  45. Mutations causing NDI include R106C, F287L, and R337X. PMID: 11916004
  46. a single amino acid difference in the first extracellular loop determines the efficiency of cell surface expression PMID: 11923476
  47. HV2R has a serine/threonine motif that is required for retention in the cytoplasm PMID: 12482593
  48. palmitoylation enhances the recruitment of beta-arrestin to the activated V2 vasopressin receptor thus facilitating processes requiring the scaffolding action of beta-arrestin PMID: 12900404
  49. V2 vasopressin receptor degradation is regulated by agonist-promoted ubiquitination PMID: 12960162
  50. examination of interaction with beta-arrestin and trafficking patterns by heterodimerization with V1 vasopressin receptor PMID: 14757828

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Involvement in disease
Nephrogenic syndrome of inappropriate antidiuresis (NSIAD); Diabetes insipidus, nephrogenic, X-linked (XNDI)
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family, Vasopressin/oxytocin receptor subfamily
Tissue Specificity
Database Links

HGNC: 897

OMIM: 300538

KEGG: hsa:554

STRING: 9606.ENSP00000338072

UniGene: Hs.567240

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