AZU1 Antibody

Code CSB-PA002485ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA002485ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) AZU1 Polyclonal antibody
Uniprot No.
Target Names
AZU1
Alternative Names
Azu 1 antibody; AZU1 antibody; Azurocidin antibody; CAP37 antibody; CAP7_HUMAN antibody; Cationic antimicrobial protein 37 antibody; Cationic antimicrobial protein CAP37 antibody; HBP antibody; Heparin binding protein antibody; Heparin-binding protein antibody; HUMAZUR antibody; Neutrophil azurocidin antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Azurocidin protein (27-251AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.
Gene References into Functions
  1. Neuronal CAP37 may modulate the neuroinflammatory response in Alzheimer disease. PMID: 26170148
  2. Plasma levels of heparin-binding protein were significantly higher in patients with acute respiratory distress syndrome. PMID: 23883488
  3. identified a multifunctional bioactive peptide, based on CAP37, that induces cell migration, possesses antibacterial and LPS-binding activity, and is effective at healing infected and noninfected corneal wounds in vivo. PMID: 25412625
  4. Azurocidin 1 displays antimicrobial activity against E. coli, S. faecalis, and C. albicans. PMID: 11994286
  5. Low levels of azurocidin in maternal serum in the first trimester were associated with subsequent preterm prelabor rupture of membranes. PMID: 23808364
  6. AZU1 exhibited high affinity binding to PTX3 in a calcium ion-dependent manner PMID: 22278372
  7. Heparin-binding protein is elevated in patients with shock from septic and non-septic etiologies. PMID: 22207392
  8. The TAASC motif in a cyclizised 20-44 amino acid peptide is part of the ligand in HBP responsible for activation of the HBP receptor on monocytes. Monocytes release HBP constitutively in small amounts and more so in the presence of lipopolysaccharide. PMID: 20083497
  9. Proliferating bile ductules may play a role in the inflammatory response in biliary atresia through expression of CAP37. PMID: 20399025
  10. group A streptococci induce contact activation and HBP release during skin infection, which likely contribute to the symptoms seen in erysipelas: fever, pain, erythema, and edema PMID: 20107486
  11. Secretion of heparin-binding protein (CAP37) from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles PMID: 11861296
  12. CAP37 is localized within the vascular endothelium associated with atherosclerotic plaques. CAP37 is induced in endothelial cells in response to inflammatory mediators PMID: 11891183
  13. structural analysis of N-glycans PMID: 12054586
  14. A comparison of proforms and mature forms of azurocidin in regulating granulopoiesis PMID: 12135665
  15. arginine-rich residues of CAP37 amplify lipopolysaccharide-induced monocyte activation PMID: 12438368
  16. CAP37 is a neutrophil-derived inflammatory mediator that augments leukocyte adhesion to endothelial monolayers PMID: 12826073
  17. Azurocidin 1 (cationic antimicrobial protein 37)is a multifunctional inflammatory mediator causing an increase of vascular permeability [review]. PMID: 14515154
  18. Due to its localization to atherosclerotic plaques and its ability to modulate smooth muscle cells, CAP37 may play a role in the progression of this disease. PMID: 15020208
  19. Secretion of CAP37, a neutrophil granule protein accumulating on the endothelial cell surface and promoting arrest of monocytes, could contribute to the recruitment of monocytes at inflammatory loci. PMID: 15879141
  20. HBP appears to be one of the primary effector molecules of antibody-mediated nonhemolytic transfusion reactions including transfusion acute lung injury PMID: 18346022
  21. HBP and human neutrophil peptides 1-3 triggered macrophage release of TNF-alpha and IFN-gamma, which acted in an autocrine loop to enhance expression of CD32 and CD64 and thereby enhance phagocytosis[heparin-binding protein, HBP] PMID: 18787642
  22. Data show that human neutrophils challenged with leukotriene B(4) release heparin-binding protein as determined by Western blot analysis. PMID: 19151333

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Subcellular Location
Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Families
Peptidase S1 family, Elastase subfamily
Database Links

HGNC: 913

OMIM: 162815

KEGG: hsa:566

STRING: 9606.ENSP00000233997

UniGene: Hs.72885

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