Acta1 Antibody

1. alpha smooth muscle actin (alphaSMA) was identified as a marker of osteoprogenitor cells in bone and periodontium. PMID: 26721734
2. WIP is a link between membrane lipid composition and actin cytoskeleton at dendritic spines. PMID: 24698977
3. ACTA1(Asp286Gly) mouse model of nemaline myopathy provide evidence of impaired in vivo muscle function, altered muscle structure and disturbed energy metabolism. PMID: 23977274
4. Combined MRI and (3)(1)P-MRS investigations of the ACTA1(H40Y) mouse model of nemaline myopathy show impaired muscle function and altered energy metabolism. PMID: 23613869
5. Data indicate roles for linkers of nucleus to cytoskeleton (LINC) molecules nesprin2giant and nesprin3, which anchor actin cap fibers to the nucleus. PMID: 23336069
6. Asp286Gly acts as a "poison-protein" and according to the computational analysis it modifies the actin-actin interface. This phenomenon is likely to prevent proper myosin cross-bridge binding. PMID: 23029319
7. Data show that upon actin binding, the two domains of utrophin become dramatically separated and ordered, indicating a transition to a single open and extended conformation. PMID: 21768337
8. Data indicated that CacyBP/SIP could simultaneously interact with tubulin and actin, suggesting that CacyBP/SIP might link actin and tubulin cytoskeletons. PMID: 20637809
9. Results provide the genetic proof that platelet production from megakaryocytes strictly requires dynamic changes in the actin cytoskeleton. PMID: 20530287
10. Data show that while increases in cardiac and vascular smooth-muscle actin can partially compensate for the lack of skeletal actin in null mice, this is not sufficient to support adequate skeletal muscle growth and/or function. PMID: 12138199
11. alpha-skeletal-muscle actin mutations have roles in development of myopathies PMID: 15226407
12. myotome pairs are transiently left-right asymmetric, with higher expression of alpha-skeletal actin and myosin light chain 3F (MLC3F) on the left side between embryonic day 9.5-10.25. PMID: 15499557
13. K+-depolarization increased Tnni1 and Acta1 mRNA levels in both differentiated C2C12 and rat skeletal muscle cells in primary culture PMID: 17146758
14. Myotubes are a suitable system to study the capacity of a mutant to incorporate into actin structures or to form or induce pathological changes. PMID: 17227580
15. Val163Met mutation in alpha-skeletal actin can affect the dynamics of other actin isoforms and severely disrupt sarcomeric structure, processes that can contribute to muscle weakness. PMID: 17705262
16. F- and G-actin concentrations in lamellipodia are about 500 microM & 150 microM, respectively. The excess of G-actin shows that the polymerization rate is not limited by diffusion & is tightly controlled by polymerization/depolymerization modulators. PMID: 19277198

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KEGG: mmu:11459

STRING: 10090.ENSMUSP00000034453

UniGene: Mm.214950