B4GALT2 Antibody

Code CSB-PA002514LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate, U251 whole cell lysate
    All lanes: B4GALT2 antibody at 3.5µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 42, 35, 45 kDa
    Observed band size: 42 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) B4GALT2 Polyclonal antibody
Uniprot No.
Target Names
B4GALT2
Alternative Names
B4GALT2; Beta-1,4-galactosyltransferase 2; Beta-1,4-GalTase 2; Beta4Gal-T2; b4Gal-T2; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; Lactose synthase A protein; N-acetyllactosamine synthase; Nal synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Beta-1,4-galactosyltransferase 2 protein (271-372AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The B4GALT2 Antibody (Product code: CSB-PA002514LA01HU) is Non-conjugated. For B4GALT2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA002514LB01HU B4GALT2 Antibody, HRP conjugated ELISA
FITC CSB-PA002514LC01HU B4GALT2 Antibody, FITC conjugated
Biotin CSB-PA002514LD01HU B4GALT2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose.
Gene References into Functions
  1. Study provides evidence that mutations in B3GNT2, B4GALT2, and ST6GALNAC2 underlie aberrant glycosylation, and contribute to the pathogenesis of molecular subsets of colon and other gastrointestinal malignancies. PMID: 27004849
  2. Significance of core 2 GlcNAc-T in the pathogenesis of capillary occlusion in diabetic retinopathy. PMID: 15504978
  3. Thus, these results suggest that among human beta4GalTs, beta4GalT-II is a major regulator of the synthesis of glycans involved in neuronal development. PMID: 15939404
  4. beta4GalT-II increases HeLa cell apoptosis induced by cisplatin depending on its Golgi localization, which indicates that beta4GalT-II might contribute to the therapeutic efficiency of cisplatin for cervix cancer. PMID: 17470362
  5. results suggested that beta1,4GalT II might serve as a target gene of p53 transcription factor during adriamycin-induced HeLa cell apoptosis, which elucidated a new mechanism of p53-mediated cell apoptosis PMID: 18211920
  6. Data show that Beta4-Gal-transferase (beta4GalT) extends core 2 and forms the backbone structure for biologically important epitopes. PMID: 19524017

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Subcellular Location
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.
Protein Families
Glycosyltransferase 7 family
Tissue Specificity
Weakly expressed in various tissues. Highest expression in prostate, testis, ovary, intestine, muscle, and in fetal brain.
Database Links

HGNC: 925

OMIM: 604013

KEGG: hsa:8704

STRING: 9606.ENSP00000310696

UniGene: Hs.632403

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