BCKDK Antibody

Datasheet

Code	CSB-PA000981
Size	US$119
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Image	Western Blot analysis of 3T3 cells using BCKDK Polyclonal Antibody Western Blot analysis of NIH-3T3 K562 Jurkat cells using BCKDK Polyclonal Antibody
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Product Details
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Target Background

Product Details

Uniprot No.

O14874

Target Names

BCKDK

Alternative Names

[3 methyl 2 oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial antibody; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase antibody; BCKD kinase antibody; BCKD-kinase antibody; BCKD_HUMAN antibody; BCKDHKIN antibody; Bckdk antibody; BCKDKD antibody; BDK antibody; Branched chain alpha keto acid dehydrogenase kinase antibody; Branched chain ketoacid dehydrogenase kinase antibody; Branched-chain alpha-ketoacid dehydrogenase kinase antibody; mitochondrial antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the N-terminal region of Human BCKDK.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, IF, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:20000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.

Gene References into Functions

our study indicates that BCKDK promotes colorectal tumorigenesis through up-regulation of the MAPK signaling pathway by phosphorylating MEK at Ser221. PMID: 28501528
There is a relationship between plamsa CST and BCKDK in sepsis patients. PMID: 27773658
Results demonstrate that BCKDK mutations can result in neurobehavioral deficits in humans. PMID: 24449431
This publication is about the mouse gene but contains the 5' sequence of the human gene, including upstream open reading frame information. PMID: 15302860
employment of multidimensional heteronuclear NMR techniques to determine the structure and dynamics of the LBD of the human branched-chain alpha-keto acid dehydrogenase complex (hbLBD) PMID: 11839747

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Involvement in disease

Branched-chain ketoacid dehydrogenase kinase deficiency (BCKDKD)

Subcellular Location

Mitochondrion matrix. Mitochondrion.

Protein Families

PDK/BCKDK protein kinase family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 16902

OMIM: 614901

KEGG: hsa:10295

STRING: 9606.ENSP00000219794

UniGene: Hs.513520

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Virus Infection Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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