BCKDK Antibody

Datasheet

Code	CSB-PA002607ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA002607ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA002607ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BCKDK Polyclonal antibody

Uniprot No.

O14874

Target Names

BCKDK

Alternative Names

[3 methyl 2 oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial antibody; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase antibody; BCKD kinase antibody; BCKD-kinase antibody; BCKD_HUMAN antibody; BCKDHKIN antibody; Bckdk antibody; BCKDKD antibody; BDK antibody; Branched chain alpha keto acid dehydrogenase kinase antibody; Branched chain ketoacid dehydrogenase kinase antibody; Branched-chain alpha-ketoacid dehydrogenase kinase antibody; mitochondrial antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial protein (153-412AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.

Gene References into Functions

our study indicates that BCKDK promotes colorectal tumorigenesis through up-regulation of the MAPK signaling pathway by phosphorylating MEK at Ser221. PMID: 28501528
There is a relationship between plamsa CST and BCKDK in sepsis patients. PMID: 27773658
Results demonstrate that BCKDK mutations can result in neurobehavioral deficits in humans. PMID: 24449431
This publication is about the mouse gene but contains the 5' sequence of the human gene, including upstream open reading frame information. PMID: 15302860
employment of multidimensional heteronuclear NMR techniques to determine the structure and dynamics of the LBD of the human branched-chain alpha-keto acid dehydrogenase complex (hbLBD) PMID: 11839747

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Involvement in disease

Branched-chain ketoacid dehydrogenase kinase deficiency (BCKDKD)

Subcellular Location

Mitochondrion matrix. Mitochondrion.

Protein Families

PDK/BCKDK protein kinase family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 16902

OMIM: 614901

KEGG: hsa:10295

STRING: 9606.ENSP00000219794

UniGene: Hs.513520

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Virus Infection Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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