Code | CSB-PA872429ESR1HU |
Size | US$166 |
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Application | Recommended Dilution |
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IHC | 1:20-1:200 |
The BCL11A antibody (CSB-PA872429ESR1HU) is used to detect the human BCL11A protein. It is produced through several steps: immunizing the rabbit with the recombinant human BCL11A protein (1-230aa), collecting the rabbit anti-serum, and purifying the BCL11A antibody from the rabbit serum. This BCL11A antibody occurs as an unconjugated IgG. Purification by antigen affinity method gives a relatively high purity to this BCL11A antibody. This BCL11A polyclonal antibody has been validated for use in ELISA and IHC applications.
Its target protein BCL11A is a zinc-finger protein highly expressed in the brain and most hematopoietic system cells. It mainly functions as a transcriptional inhibitor crucial in the brain and hematopoietic system development, as well as fetal-to-adult hemoglobin switching. Upregulation of BCL11A was detected in hematological malignancies and some malignant solid tumors, such as triple-negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC).
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