BLOC1S1 Antibody

Datasheet

Code	CSB-PA00495A0Rb
Size	US$166
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Image	Western blot All lanes: BLOC1S1 antibody at 2µg/ml Lane 1: EC109 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 18, 15 kDa Observed band size: 75 kDa Immunofluorescent analysis of HepG2 cells using CSB-PA00495A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA00495A0Rb at dilution of 1:100 Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA00495A0Rb at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BLOC1S1 Polyclonal antibody

Uniprot No.

P78537

Target Names

BLOC1S1

Alternative Names

BLOC1S1 antibody; BLOS1 antibody; GCN5L1 antibody; RT14Biogenesis of lysosome-related organelles complex 1 subunit 1 antibody; BLOC-1 subunit 1 antibody; GCN5-like protein 1 antibody; Protein RT14 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 1 protein (1-153AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The BLOC1S1 Antibody (Product code: CSB-PA00495A0Rb) is Non-conjugated. For BLOC1S1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA00495B0Rb	BLOC1S1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA00495C0Rb	BLOC1S1 Antibody, FITC conjugated
Biotin	CSB-PA00495D0Rb	BLOC1S1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.; May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.

Gene References into Functions

The Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulators of the actin cytoskeleton. PMID: 23676666
BLOS1 interacts with KXD1. PMID: 22554196
GCN5L1 interacts with and promotes acetylation of SIRT3 respiratory chain targets and reverses global SIRT3 effects on mitochondrial protein acetylation, respiration and bioenergetics PMID: 22309213
Quantitative proteomic studies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecular pathways of schizophrenia susceptibility. PMID: 22423091
GCN5L1/BLOC1S1 regulates lysine acetylation in mitochondria. PMID: 22309213
Together this study data provide evidence for the involvement of the BLOC-1 protein complex in SZ pathogenesis. PMID: 17618940
Experimental investigation of five specific genes, AP3B1, ATP6AP1, BLOC1S1, LAMP2, and RAB11A, has confirmed novel roles for these proteins in the proper initiation of macroautophagy in amino acid-starved fibroblasts. PMID: 19246570
Biogenesis of Lysosome-related Organelles complex-1 (BLOC-1) subunit 1 (BLOS1). PMID: 15102850

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Subcellular Location

Mitochondrion intermembrane space. Mitochondrion matrix. Cytoplasm, cytosol. Lysosome membrane.

Protein Families

BLOC1S1 family

Database Links

HGNC: 4200

OMIM: 601444

KEGG: hsa:2647

STRING: 9606.ENSP00000447537

UniGene: Hs.600940

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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