BLOC1S6 Antibody

Datasheet

Code	CSB-PA890745DSR2HU
Size	US$166
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Image	Western blot All lanes: BLOC1S6 antibody at 3.33µg/ml Lane 1: A431 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 20, 9 kDa Observed band size: 20 kDa Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA890745DSR2HU at dilution of 1:100 Immunoprecipitating BLOC1S6 in HEK293 whole cell lysate Lane 1: Rabbit control IgG instead of (1µg) instead of CSB-PA890745DSR2HU in HEK293 whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000) Lane 2: CSB-PA890745DSR2HU (4µg) + HEK293 whole cell lysate (500µg) Lane 3: HEK293 whole cell lysate (20µg)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BLOC1S6 Polyclonal antibody

Uniprot No.

Q9UL45

Target Names

BLOC1S6

Alternative Names

Bloc1s6 antibody; iogenesis of lysosome-related organelles complex 1 subunit 6 antibody; PA antibody; Pallid (mouse) homolog antibody; PALLID antibody; Pallid protein antibody; Pallid protein homolog antibody; Pallidin antibody; Pallidin homolog (mouse) antibody; PLDN antibody; PLDN_HUMAN antibody; Syntaxin 13 binding protein antibody; Syntaxin 13-interacting protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 6 protein (1-170AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC, IP

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IP	1:200-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunoprecipitation (IP) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

Gene References into Functions

Results from a study on gene expression variability markers in early-stage human embryos shows that BLOC1S6 (PLDN) is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
PLDN is a direct target of RUNX1 and its dysregulation is a mechanism for platelet dense granule deficiency associated with RUNX1 haplodeficiency PMID: 28075530
Mecp2 regulates the expression of components belonging to the dysbindin interactome PMID: 23750231
role in biogenesis of lysosome-related organelles PMID: 12191018
no defects in the known components of pallidin-muted complex (BLOC-1)have been identified in 142 patients with HPS, suggesting that BLOC-1 function may be critical in humans. PMID: 12576321

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Involvement in disease

Hermansky-Pudlak syndrome 9 (HPS9)

Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein.

Protein Families

BLOC1S6 family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 8549

OMIM: 604310

KEGG: hsa:26258

STRING: 9606.ENSP00000220531

UniGene: Hs.7037

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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