BMP10 Antibody

Datasheet

Code	CSB-PA002734LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA002734LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BMP10 Polyclonal antibody

Uniprot No.

O95393

Target Names

BMP10

Alternative Names

BMP-10 antibody; Bmp10 antibody; BMP10_HUMAN antibody; Bone morphogenetic protein 10 antibody; Bone morphogenetic protein 10 preproprotein antibody; MGC126783 antibody; OTTHUMP00000159973 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Bone morphogenetic protein 10 protein (317-424AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The BMP10 Antibody (Product code: CSB-PA002734LA01HU) is Non-conjugated. For BMP10 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA002734LB01HU	BMP10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002734LC01HU	BMP10 Antibody, FITC conjugated
Biotin	CSB-PA002734LD01HU	BMP10 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.

Gene References into Functions

Data suggest BMP9/GDF2 and BMP10 synergize with TNFA to increase monocyte recruitment to vascular endothelial cells; process appears to be mediated mainly via ALK2/ACVR1 (which exhibits protein kinase activity). These studies used in vitro flow monocyte adhesion assay. (BMP9 = growth differentiation factor 2; BMP10 = bone morphogenetic protein 10; TNFA = tumor necrosis factor alpha; ALK2/ACVR1 = activin A receptor type 1) PMID: 28646109
Bone morphogenetic protein (BMP)9 and BMP10 are high affinity ligands for activin receptor-like kinase 1 (ALK1). PMID: 27528761
Forced expression of BMP10 in gastric cancer (GC) cells inhibited its growth and migration, while knocking down the expression of BMP10 in GC cells promoted cell growth, migration, and metastasis. PMID: 26419594
The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells. PMID: 26631724
BMP10, is elevated in the stenotic colon segment of Hirschsprung disease patients, and BMP10 signaling may play a pivotal role in disease development. PMID: 24551273
Low expression of bone morphogenetic protein-10 is associated with urothelial cancer of the bladder. PMID: 23645739
Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. PMID: 21737454
Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. PMID: 21550985
Bone morphogenetic protein-10 (BMP-10) may function as a tumor suppressor in breast cancer. PMID: 20608934
Hypertension induced expression of prohypertrophic BMP10, and the hypertrophic effect of BMP10 was modulated, at least in part, by its binding to Tcap at the Z disc. PMID: 17921333
Describes the cloning and expression of murine BMP-10. PMID: 10072785

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Subcellular Location

Secreted.

Protein Families

TGF-beta family

Tissue Specificity

Detected in mammary epithelia (at protein level).

Database Links

HGNC: 20869

OMIM: 608748

KEGG: hsa:27302

STRING: 9606.ENSP00000295379

UniGene: Hs.158317

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Protein Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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