BMPER Antibody

Datasheet

Code	CSB-PA839829LA01HU
Size	US$166
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Image	IHC image of CSB-PA839829LA01HU diluted at 1:200 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BMPER Polyclonal antibody

Uniprot No.

Q8N8U9

Target Names

BMPER

Alternative Names

BMP binding endothelial regulator antibody; BMP binding endothelial regulator precursor protein antibody; BMP-binding endothelial regulator protein antibody; BMPER antibody; BMPER_HUMAN antibody; Bone morphogenetic protein binding endothelial cell precursor derived regulator antibody; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator antibody; CRIM3 antibody; Crossveinless 2 antibody; CV 2 antibody; CV2 antibody; hCV2 antibody; Protein crossveinless 2 antibody; Protein crossveinless-2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human BMP-binding endothelial regulator protein (271-418AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The BMPER Antibody (Product code: CSB-PA839829LA01HU) is Non-conjugated. For BMPER Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA839829LB01HU	BMPER Antibody, HRP conjugated	ELISA
FITC	CSB-PA839829LC01HU	BMPER Antibody, FITC conjugated
Biotin	CSB-PA839829LD01HU	BMPER Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.

Gene References into Functions

Overexpression of BMPER remarkably enhanced BMP-2-induced osteogenic differentiation, while suppression of BMPER effectively inhibited this process both in vitro and in vivo. PMID: 29518774
that BMPER-modulated BMP pathway activity regulates VE-cadherin expression and vascular barrier function PMID: 27995357
BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis. PMID: 26467725
BMPER-dependent pathway involved in high glucose induced alkaline phosphatase expression in vascular smooth muscle cells. PMID: 26264461
The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. PMID: 25503991
BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs. PMID: 22778264
Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. PMID: 22772758
The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. PMID: 22020334
Mutual regulation by BMP-9 and CV2 is essential in regulating the development of the vascular endothelium. PMID: 22474252
Diaphonospondylodysostosis is caused by loss of BMPER function. PMID: 21990102
BMPER-mediated signaling plays an essential role in vertebral segmentation early in human development, while defects in BMPER produce Diaphanospondylodysostosis. PMID: 20869035
BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity PMID: 12897139
Crossveinless-2 is an inhibitor of BMP function PMID: 14766204
BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. PMID: 18787191

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Involvement in disease

Diaphanospondylodysostosis (DSD)

Subcellular Location

Secreted.

Tissue Specificity

Highly expressed in lung, and brain and also in primary chondrocytes.

Database Links

HGNC: 24154

OMIM: 608022

KEGG: hsa:168667

STRING: 9606.ENSP00000297161

UniGene: Hs.660998

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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